Detection of 1,2-hydride shifts in the formation of euph-7-ene by the squalene-tetrahymanol cyclase of Tetrahymena pyriformis

José Luis Giner; Stefano Rocchetti; Serge Neunlist; Michel Rohmer; Duilio Arigoni

doi:10.1039/b504300j

Detection of 1,2-hydride shifts in the formation of euph-7-ene by the squalene-tetrahymanol cyclase of Tetrahymena pyriformis

José Luis Giner
, Stefano Rocchetti
, Serge Neunlist
, Michel Rohmer
, Duilio Arigoni

Chemistry

College of Environmental Science & Forestry

Swiss Federal Institute of Technology Zurich
Université de Haute-Alsace
Université de Strasbourg

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

Incubation of samples of 2,3-dihydrosqualene, specifically labeled with deuterium at either carbon position 7 or 11, with an enzyme extract from Tetrahymena pyriformis, containing a squalene-tetrahymanol cyclase, provided specimens of euph-7-enes displaying deuterium patterns consistent with the biosynthetic operation of two consecutive 1,2-hydride shifts.

Original language	English
Pages (from-to)	3089-3091
Number of pages	3
Journal	Chemical Communications
Issue number	24
DOIs	https://doi.org/10.1039/b504300j
State	Published - Jun 28 2005

Access to Document

10.1039/b504300j

Cite this

@article{ebadc63ff7fe4b388528c95d7354bc80,

title = "Detection of 1,2-hydride shifts in the formation of euph-7-ene by the squalene-tetrahymanol cyclase of Tetrahymena pyriformis",

abstract = "Incubation of samples of 2,3-dihydrosqualene, specifically labeled with deuterium at either carbon position 7 or 11, with an enzyme extract from Tetrahymena pyriformis, containing a squalene-tetrahymanol cyclase, provided specimens of euph-7-enes displaying deuterium patterns consistent with the biosynthetic operation of two consecutive 1,2-hydride shifts.",

author = "Giner, \{Jos{\'e} Luis\} and Stefano Rocchetti and Serge Neunlist and Michel Rohmer and Duilio Arigoni",

year = "2005",

month = jun,

day = "28",

doi = "10.1039/b504300j",

language = "English",

pages = "3089--3091",

journal = "Chemical Communications",

issn = "1359-7345",

number = "24",

}

TY - JOUR

T1 - Detection of 1,2-hydride shifts in the formation of euph-7-ene by the squalene-tetrahymanol cyclase of Tetrahymena pyriformis

AU - Giner, José Luis

AU - Rocchetti, Stefano

AU - Neunlist, Serge

AU - Rohmer, Michel

AU - Arigoni, Duilio

PY - 2005/6/28

Y1 - 2005/6/28

N2 - Incubation of samples of 2,3-dihydrosqualene, specifically labeled with deuterium at either carbon position 7 or 11, with an enzyme extract from Tetrahymena pyriformis, containing a squalene-tetrahymanol cyclase, provided specimens of euph-7-enes displaying deuterium patterns consistent with the biosynthetic operation of two consecutive 1,2-hydride shifts.

AB - Incubation of samples of 2,3-dihydrosqualene, specifically labeled with deuterium at either carbon position 7 or 11, with an enzyme extract from Tetrahymena pyriformis, containing a squalene-tetrahymanol cyclase, provided specimens of euph-7-enes displaying deuterium patterns consistent with the biosynthetic operation of two consecutive 1,2-hydride shifts.

UR - https://www.scopus.com/pages/publications/21844475444

U2 - 10.1039/b504300j

DO - 10.1039/b504300j

M3 - Article

C2 - 15959594

SN - 1359-7345

SP - 3089

EP - 3091

JO - Chemical Communications

JF - Chemical Communications

IS - 24

ER -

Detection of 1,2-hydride shifts in the formation of euph-7-ene by the squalene-tetrahymanol cyclase of Tetrahymena pyriformis

Abstract

Access to Document

Other files and links

Fingerprint

Cite this