Detection of single nanoparticles and lentiviruses using microcavity resonance broadening

Linbo Shao; Xue Feng Jiang; Xiao Chong Yu; Bei Bei Li; William R. Clements; Frank Vollmer; Wei Wang; Yun Feng Xiao; Qihuang Gong

doi:10.1002/adma201302572

Detection of single nanoparticles and lentiviruses using microcavity resonance broadening

Linbo Shao
, Xue Feng Jiang
, Xiao Chong Yu
, Bei Bei Li
, William R. Clements
, Frank Vollmer
, Wei Wang
, Yun Feng Xiao
, Qihuang Gong

Physics

Binghamton University

Peking University
Max Planck Institute for the Science of Light
CAS - Institute of Microelectronics

Research output: Contribution to journal › Article › peer-review

312 Scopus citations

Abstract

A new label-free sensing mechanism is demonstrated experimentally by monitoring the whispering-gallery mode broadening in microcavities. It is immune to both noise from the probe laser and environmental disturbances, and is able to remove the strict requirement for ultra-high-Q mode cavities for sensitive nanoparticle detection. This ability to sense nanoscale objects and biological analytes is particularly crucial for wide applications.

Original language	English
Pages (from-to)	5616-5620
Number of pages	5
Journal	Advanced Materials
Volume	25
Issue number	39
DOIs	https://doi.org/10.1002/adma201302572
State	Published - Oct 18 2013

Keywords

label-free biosensing
microcavity mode broadening
nanoparticle detection
rayleigh scattering
whispering gallery mode

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10.1002/adma201302572

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abstract = "A new label-free sensing mechanism is demonstrated experimentally by monitoring the whispering-gallery mode broadening in microcavities. It is immune to both noise from the probe laser and environmental disturbances, and is able to remove the strict requirement for ultra-high-Q mode cavities for sensitive nanoparticle detection. This ability to sense nanoscale objects and biological analytes is particularly crucial for wide applications.",

keywords = "label-free biosensing, microcavity mode broadening, nanoparticle detection, rayleigh scattering, whispering gallery mode",

author = "Linbo Shao and Jiang, \{Xue Feng\} and Yu, \{Xiao Chong\} and Li, \{Bei Bei\} and Clements, \{William R.\} and Frank Vollmer and Wei Wang and Xiao, \{Yun Feng\} and Qihuang Gong",

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T1 - Detection of single nanoparticles and lentiviruses using microcavity resonance broadening

AU - Shao, Linbo

AU - Jiang, Xue Feng

AU - Yu, Xiao Chong

AU - Li, Bei Bei

AU - Clements, William R.

AU - Vollmer, Frank

AU - Wang, Wei

AU - Xiao, Yun Feng

AU - Gong, Qihuang

PY - 2013/10/18

Y1 - 2013/10/18

N2 - A new label-free sensing mechanism is demonstrated experimentally by monitoring the whispering-gallery mode broadening in microcavities. It is immune to both noise from the probe laser and environmental disturbances, and is able to remove the strict requirement for ultra-high-Q mode cavities for sensitive nanoparticle detection. This ability to sense nanoscale objects and biological analytes is particularly crucial for wide applications.

AB - A new label-free sensing mechanism is demonstrated experimentally by monitoring the whispering-gallery mode broadening in microcavities. It is immune to both noise from the probe laser and environmental disturbances, and is able to remove the strict requirement for ultra-high-Q mode cavities for sensitive nanoparticle detection. This ability to sense nanoscale objects and biological analytes is particularly crucial for wide applications.

KW - label-free biosensing

KW - microcavity mode broadening

KW - nanoparticle detection

KW - rayleigh scattering

KW - whispering gallery mode

UR - https://www.scopus.com/pages/publications/84886297630

U2 - 10.1002/adma201302572

DO - 10.1002/adma201302572

M3 - Article

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VL - 25

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JO - Advanced Materials

JF - Advanced Materials

IS - 39

ER -

Detection of single nanoparticles and lentiviruses using microcavity resonance broadening

Abstract

Keywords

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