Differential effects of baclofen and γ-aminobutyric acid (GABA) on rat piriform cortex pyramidal neurons in vitro

Naomi Doi; David O. Carpenter; Nobuaki Hori

doi:10.1007/BF00712849

Differential effects of baclofen and γ-aminobutyric acid (GABA) on rat piriform cortex pyramidal neurons in vitro

Naomi Doi
, David O. Carpenter
, Nobuaki Hori

Environmental Health Sciences

University at Albany

Kyushu University
Wadsworth Center for Laboratories and Research

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

1. The effects of baclofen and GABA on rat piriform cortex neurons were investigated electrophysiologically using a brain slice preparation. 2. At resting potential GABA depolarized and baclofen hyperpolarized the cell, probably through activation of Cl and K conductances acting at GABA_A and GABA_B receptors, respectively. 3. The GABA_A receptors were concentrated on the apical and basal dendrites near the cell body, while the baclofen-sensitive GABA receptors were concentrated particularly on the basal dendrites. 4. The different distributions of receptor localization must have functional consequences which remain to be elucidated.

Original language	English
Pages (from-to)	559-564
Number of pages	6
Journal	Cellular and Molecular Neurobiology
Volume	10
Issue number	4
DOIs	https://doi.org/10.1007/BF00712849
State	Published - Dec 1990

Keywords

GABA receptors
brain slices
piriform cortex
γ-aminobutyric acid (GABA)

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10.1007/BF00712849

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title = "Differential effects of baclofen and γ-aminobutyric acid (GABA) on rat piriform cortex pyramidal neurons in vitro",

abstract = "1. The effects of baclofen and GABA on rat piriform cortex neurons were investigated electrophysiologically using a brain slice preparation. 2. At resting potential GABA depolarized and baclofen hyperpolarized the cell, probably through activation of Cl and K conductances acting at GABAA and GABAB receptors, respectively. 3. The GABAA receptors were concentrated on the apical and basal dendrites near the cell body, while the baclofen-sensitive GABA receptors were concentrated particularly on the basal dendrites. 4. The different distributions of receptor localization must have functional consequences which remain to be elucidated.",

keywords = "GABA receptors, brain slices, piriform cortex, γ-aminobutyric acid (GABA)",

author = "Naomi Doi and Carpenter, \{David O.\} and Nobuaki Hori",

year = "1990",

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journal = "Cellular and Molecular Neurobiology",

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T1 - Differential effects of baclofen and γ-aminobutyric acid (GABA) on rat piriform cortex pyramidal neurons in vitro

AU - Doi, Naomi

AU - Carpenter, David O.

AU - Hori, Nobuaki

PY - 1990/12

Y1 - 1990/12

N2 - 1. The effects of baclofen and GABA on rat piriform cortex neurons were investigated electrophysiologically using a brain slice preparation. 2. At resting potential GABA depolarized and baclofen hyperpolarized the cell, probably through activation of Cl and K conductances acting at GABAA and GABAB receptors, respectively. 3. The GABAA receptors were concentrated on the apical and basal dendrites near the cell body, while the baclofen-sensitive GABA receptors were concentrated particularly on the basal dendrites. 4. The different distributions of receptor localization must have functional consequences which remain to be elucidated.

AB - 1. The effects of baclofen and GABA on rat piriform cortex neurons were investigated electrophysiologically using a brain slice preparation. 2. At resting potential GABA depolarized and baclofen hyperpolarized the cell, probably through activation of Cl and K conductances acting at GABAA and GABAB receptors, respectively. 3. The GABAA receptors were concentrated on the apical and basal dendrites near the cell body, while the baclofen-sensitive GABA receptors were concentrated particularly on the basal dendrites. 4. The different distributions of receptor localization must have functional consequences which remain to be elucidated.

KW - GABA receptors

KW - brain slices

KW - piriform cortex

KW - γ-aminobutyric acid (GABA)

UR - https://www.scopus.com/pages/publications/0025689602

U2 - 10.1007/BF00712849

DO - 10.1007/BF00712849

M3 - Article

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SN - 0272-4340

VL - 10

SP - 559

EP - 564

JO - Cellular and Molecular Neurobiology

JF - Cellular and Molecular Neurobiology

IS - 4

ER -

Differential effects of baclofen and γ-aminobutyric acid (GABA) on rat piriform cortex pyramidal neurons in vitro

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Keywords

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