Differential inhibition of globin chain synthesis by tosyl-L-lysyl chloromethyl ketone

Majambu Mbikay; Michael D. Garrick

doi:10.1016/0024-3205(81)90518-X

Differential inhibition of globin chain synthesis by tosyl-L-lysyl chloromethyl ketone

Majambu Mbikay
, Michael D. Garrick

Biochemistry

University at Buffalo

SUNY Buffalo

Research output: Contribution to journal › Article › peer-review

Abstract

Tosyl-L-lysyl chloromethyl ketone (TLCK), added to an incubation of rabbit reticulocytes, inhibits the synthesis of α globin chain more than that of β chain. TLCK has been previously shown to inhibit initiation of translation in a variety of cells. Thus this drug could be used to test for such a differential effect at the level of peptide initiation on the various mRNAs in these cells.

Original language	English
Pages (from-to)	1873-1879
Number of pages	7
Journal	Life Sciences
Volume	29
Issue number	18
DOIs	https://doi.org/10.1016/0024-3205(81)90518-X
State	Published - Nov 2 1981

Access to Document

10.1016/0024-3205(81)90518-X

Cite this

@article{daef61779df94e6a8af53ee41a2b9b72,

title = "Differential inhibition of globin chain synthesis by tosyl-L-lysyl chloromethyl ketone",

abstract = "Tosyl-L-lysyl chloromethyl ketone (TLCK), added to an incubation of rabbit reticulocytes, inhibits the synthesis of α globin chain more than that of β chain. TLCK has been previously shown to inhibit initiation of translation in a variety of cells. Thus this drug could be used to test for such a differential effect at the level of peptide initiation on the various mRNAs in these cells.",

author = "Majambu Mbikay and Garrick, \{Michael D.\}",

year = "1981",

month = nov,

day = "2",

doi = "10.1016/0024-3205(81)90518-X",

language = "English",

volume = "29",

pages = "1873--1879",

journal = "Life Sciences",

issn = "0024-3205",

publisher = "Elsevier Inc.",

number = "18",

}

TY - JOUR

T1 - Differential inhibition of globin chain synthesis by tosyl-L-lysyl chloromethyl ketone

AU - Mbikay, Majambu

AU - Garrick, Michael D.

PY - 1981/11/2

Y1 - 1981/11/2

N2 - Tosyl-L-lysyl chloromethyl ketone (TLCK), added to an incubation of rabbit reticulocytes, inhibits the synthesis of α globin chain more than that of β chain. TLCK has been previously shown to inhibit initiation of translation in a variety of cells. Thus this drug could be used to test for such a differential effect at the level of peptide initiation on the various mRNAs in these cells.

AB - Tosyl-L-lysyl chloromethyl ketone (TLCK), added to an incubation of rabbit reticulocytes, inhibits the synthesis of α globin chain more than that of β chain. TLCK has been previously shown to inhibit initiation of translation in a variety of cells. Thus this drug could be used to test for such a differential effect at the level of peptide initiation on the various mRNAs in these cells.

UR - https://www.scopus.com/pages/publications/0019817531

U2 - 10.1016/0024-3205(81)90518-X

DO - 10.1016/0024-3205(81)90518-X

M3 - Article

C2 - 7311721

SN - 0024-3205

VL - 29

SP - 1873

EP - 1879

JO - Life Sciences

JF - Life Sciences

IS - 18

ER -

Differential inhibition of globin chain synthesis by tosyl-L-lysyl chloromethyl ketone

Abstract

Access to Document

Other files and links

Fingerprint

Cite this