Differentiation of acute promyelocytic leukemia cell induced by 1,25- dihydroxyvitamin D3 and pentoxifylline (Trental®)

M. Srivastava; J. L. Ambrus

Differentiation of acute promyelocytic leukemia cell induced by 1,25- dihydroxyvitamin D3 and pentoxifylline (Trental®)

M. Srivastava
, J. L. Ambrus

Medicine

University at Buffalo

Women and Children's Hospital of Buffalo

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Human promyelocytic leukemia cell line HL-60 in tissue culture was treated with various concentrations of 1,25-dihydroxyvitamin D3, (D3) pentoxifylline (Px) or in combinations. Differentiation to normal granulocytes or monocytes was evaluated by nitroblue tetrazolium (NBT) reducing capacity and morphologic criteria. (D3) produced monocytic differentiation, but sub- differentiation inducing doses of (Px) had no effect. In previous studies we found higher doses of (Px) to produce granulocytic differentiation in vitro and in vivo.

Original language	English
Pages (from-to)	385-388
Number of pages	4
Journal	Research Communications in Chemical Pathology and Pharmacology
Volume	79
Issue number	3
State	Published - 1993

Cite this

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abstract = "Human promyelocytic leukemia cell line HL-60 in tissue culture was treated with various concentrations of 1,25-dihydroxyvitamin D3, (D3) pentoxifylline (Px) or in combinations. Differentiation to normal granulocytes or monocytes was evaluated by nitroblue tetrazolium (NBT) reducing capacity and morphologic criteria. (D3) produced monocytic differentiation, but sub- differentiation inducing doses of (Px) had no effect. In previous studies we found higher doses of (Px) to produce granulocytic differentiation in vitro and in vivo.",

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AU - Srivastava, M.

AU - Ambrus, J. L.

PY - 1993

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N2 - Human promyelocytic leukemia cell line HL-60 in tissue culture was treated with various concentrations of 1,25-dihydroxyvitamin D3, (D3) pentoxifylline (Px) or in combinations. Differentiation to normal granulocytes or monocytes was evaluated by nitroblue tetrazolium (NBT) reducing capacity and morphologic criteria. (D3) produced monocytic differentiation, but sub- differentiation inducing doses of (Px) had no effect. In previous studies we found higher doses of (Px) to produce granulocytic differentiation in vitro and in vivo.

AB - Human promyelocytic leukemia cell line HL-60 in tissue culture was treated with various concentrations of 1,25-dihydroxyvitamin D3, (D3) pentoxifylline (Px) or in combinations. Differentiation to normal granulocytes or monocytes was evaluated by nitroblue tetrazolium (NBT) reducing capacity and morphologic criteria. (D3) produced monocytic differentiation, but sub- differentiation inducing doses of (Px) had no effect. In previous studies we found higher doses of (Px) to produce granulocytic differentiation in vitro and in vivo.

UR - https://www.scopus.com/pages/publications/0027409457

M3 - Article

C2 - 8480085

SN - 0034-5164

VL - 79

SP - 385

EP - 388

JO - Research Communications in Chemical Pathology and Pharmacology

JF - Research Communications in Chemical Pathology and Pharmacology

IS - 3

ER -

Differentiation of acute promyelocytic leukemia cell induced by 1,25- dihydroxyvitamin D3 and pentoxifylline (Trental®)

Abstract

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