Dinuclear copper(II) complexes that promote hydrolysis of GpppG, a model for the 5′-cap of mRNA

Kevin P. McCue; David A. Voss; Christian Marks; Janet R. Morrow

doi:10.1039/a805916k

Dinuclear copper(II) complexes that promote hydrolysis of GpppG, a model for the 5′-cap of mRNA

Kevin P. McCue
, David A. Voss
, Christian Marks
, Janet R. Morrow

Chemistry

University at Buffalo

SUNY Buffalo

Research output: Contribution to journal › Article › peer-review

40 Scopus citations

Abstract

The hydrolysis of the monoribonucleotide GpppG, a model compound for the 5′-cap structure of mRNA, by dinuclear Cu(II) complexes of triazacyclononane was 100-fold more rapid than in the presense of the analogous mononuclear complex; a first-order or second-order dependence on the catalyst was observed for two different dinuclear complexes.

Original language	English
Pages (from-to)	2961-2963
Number of pages	3
Journal	Journal of the Chemical Society. Dalton Transactions
Issue number	18
DOIs	https://doi.org/10.1039/a805916k
State	Published - Sep 21 1998

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title = "Dinuclear copper(II) complexes that promote hydrolysis of GpppG, a model for the 5′-cap of mRNA",

abstract = "The hydrolysis of the monoribonucleotide GpppG, a model compound for the 5′-cap structure of mRNA, by dinuclear Cu(II) complexes of triazacyclononane was 100-fold more rapid than in the presense of the analogous mononuclear complex; a first-order or second-order dependence on the catalyst was observed for two different dinuclear complexes.",

author = "McCue, \{Kevin P.\} and Voss, \{David A.\} and Christian Marks and Morrow, \{Janet R.\}",

year = "1998",

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language = "English",

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journal = "Journal of the Chemical Society. Dalton Transactions",

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T1 - Dinuclear copper(II) complexes that promote hydrolysis of GpppG, a model for the 5′-cap of mRNA

AU - McCue, Kevin P.

AU - Voss, David A.

AU - Marks, Christian

AU - Morrow, Janet R.

PY - 1998/9/21

Y1 - 1998/9/21

N2 - The hydrolysis of the monoribonucleotide GpppG, a model compound for the 5′-cap structure of mRNA, by dinuclear Cu(II) complexes of triazacyclononane was 100-fold more rapid than in the presense of the analogous mononuclear complex; a first-order or second-order dependence on the catalyst was observed for two different dinuclear complexes.

AB - The hydrolysis of the monoribonucleotide GpppG, a model compound for the 5′-cap structure of mRNA, by dinuclear Cu(II) complexes of triazacyclononane was 100-fold more rapid than in the presense of the analogous mononuclear complex; a first-order or second-order dependence on the catalyst was observed for two different dinuclear complexes.

UR - https://www.scopus.com/pages/publications/33749084503

U2 - 10.1039/a805916k

DO - 10.1039/a805916k

M3 - Article

SN - 1470-479X

SP - 2961

EP - 2963

JO - Journal of the Chemical Society. Dalton Transactions

JF - Journal of the Chemical Society. Dalton Transactions

IS - 18

ER -

Dinuclear copper(II) complexes that promote hydrolysis of GpppG, a model for the 5′-cap of mRNA

Abstract

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