Disseminated Mycoplasma Orale Infection in Patients With Phosphoinositide-3-Kinase Regulatory Subunit 1 Mutations

Arthur H. Totten; Gulbu Uzel; Pavel P. Khil; Jung Ho Youn; Jennifer Treat; Craig D. Soutar; Steven M. Holland; John P. Dekker; Christa S. Zerbe

doi:10.1093/ofid/ofac472

Disseminated Mycoplasma Orale Infection in Patients With Phosphoinositide-3-Kinase Regulatory Subunit 1 Mutations

Arthur H. Totten
, Gulbu Uzel
, Pavel P. Khil
, Jung Ho Youn
, Jennifer Treat
, Craig D. Soutar
, Steven M. Holland
, John P. Dekker
, Christa S. Zerbe

Pathology

Stony Brook University

National Institutes of Health

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Mycoplasma orale is a rare cause of invasive infection in immunodeficient hosts. Phosphatidylinositol 3-kinase, regulatory subunit 1 (PI3KR1) mutations predispose patients to sinopulmonary infections, alongside bronchiectasis autoimmunity and lymphoproliferation. We report 2 cases of PI3KR1 deficiency with invasive M orale and effective treatment options.

Original language	English
Article number	ofac472
Journal	Open Forum Infectious Diseases
Volume	9
Issue number	9
DOIs	https://doi.org/10.1093/ofid/ofac472
State	Published - Sep 2022

Keywords

Mycoplasma orale
PI3KR1
immunodeficiency
phosphoinositide-3-kinase regulatory subunit 1

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10.1093/ofid/ofac472

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title = "Disseminated Mycoplasma Orale Infection in Patients With Phosphoinositide-3-Kinase Regulatory Subunit 1 Mutations",

abstract = "Mycoplasma orale is a rare cause of invasive infection in immunodeficient hosts. Phosphatidylinositol 3-kinase, regulatory subunit 1 (PI3KR1) mutations predispose patients to sinopulmonary infections, alongside bronchiectasis autoimmunity and lymphoproliferation. We report 2 cases of PI3KR1 deficiency with invasive M orale and effective treatment options.",

keywords = "Mycoplasma orale, PI3KR1, immunodeficiency, phosphoinositide-3-kinase regulatory subunit 1",

author = "Totten, \{Arthur H.\} and Gulbu Uzel and Khil, \{Pavel P.\} and Youn, \{Jung Ho\} and Jennifer Treat and Soutar, \{Craig D.\} and Holland, \{Steven M.\} and Dekker, \{John P.\} and Zerbe, \{Christa S.\}",

note = "Publisher Copyright: {\textcopyright} The Author(s) 2022.",

year = "2022",

month = sep,

doi = "10.1093/ofid/ofac472",

language = "English",

volume = "9",

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T1 - Disseminated Mycoplasma Orale Infection in Patients With Phosphoinositide-3-Kinase Regulatory Subunit 1 Mutations

AU - Totten, Arthur H.

AU - Uzel, Gulbu

AU - Khil, Pavel P.

AU - Youn, Jung Ho

AU - Treat, Jennifer

AU - Soutar, Craig D.

AU - Holland, Steven M.

AU - Dekker, John P.

AU - Zerbe, Christa S.

PY - 2022/9

Y1 - 2022/9

N2 - Mycoplasma orale is a rare cause of invasive infection in immunodeficient hosts. Phosphatidylinositol 3-kinase, regulatory subunit 1 (PI3KR1) mutations predispose patients to sinopulmonary infections, alongside bronchiectasis autoimmunity and lymphoproliferation. We report 2 cases of PI3KR1 deficiency with invasive M orale and effective treatment options.

AB - Mycoplasma orale is a rare cause of invasive infection in immunodeficient hosts. Phosphatidylinositol 3-kinase, regulatory subunit 1 (PI3KR1) mutations predispose patients to sinopulmonary infections, alongside bronchiectasis autoimmunity and lymphoproliferation. We report 2 cases of PI3KR1 deficiency with invasive M orale and effective treatment options.

KW - Mycoplasma orale

KW - PI3KR1

KW - immunodeficiency

KW - phosphoinositide-3-kinase regulatory subunit 1

UR - https://www.scopus.com/pages/publications/85159636531

U2 - 10.1093/ofid/ofac472

DO - 10.1093/ofid/ofac472

M3 - Article

SN - 2328-8957

VL - 9

JO - Open Forum Infectious Diseases

JF - Open Forum Infectious Diseases

IS - 9

M1 - ofac472

ER -

Disseminated Mycoplasma Orale Infection in Patients With Phosphoinositide-3-Kinase Regulatory Subunit 1 Mutations

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Keywords

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