DNA electrophoresis on two-dimensional arrays of SiO2 beads

Y. S. Seo; V. A. Samuilov; J. Sokolov; M. Rafailovich; D. Gersappe; B. Chu

DNA electrophoresis on two-dimensional arrays of SiO₂ beads

Materials Science and Engineering

Stony Brook University

Stony Brook University

Research output: Contribution to journal › Conference article › peer-review

Abstract

A novel approach of fabricating 2-D arrays of SiO₂ beads on a Si surface using the Langmuir-Blodgett (LB) technique is reported. The corrugated surfaces were tested as a separation media for surface electrophoresis of DNA molecules. The measured electrophoretic mobility for λ-DNA is only 20% slower than previously measured on a flat Si wafer. This indicates that the separation mechanism is due to surface friction rather than biased reptation as reported by Tinland in the three dimensional Silica bead matrix where the mobility is two orders of magnitude smaller.

Original language	English
Pages (from-to)	D371-D375
Journal	Materials Research Society Symposium - Proceedings
Volume	636
State	Published - 2001
Event	Nonlithigraphic and Lithographic Methods of Nanofabrication -From Ultralarge-Scale Integration to Photonics to Molecular Electronics - Boston, MA, United States Duration: Nov 26 2000 → Dec 1 2000

Cite this

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title = "DNA electrophoresis on two-dimensional arrays of SiO2 beads",

abstract = "A novel approach of fabricating 2-D arrays of SiO2 beads on a Si surface using the Langmuir-Blodgett (LB) technique is reported. The corrugated surfaces were tested as a separation media for surface electrophoresis of DNA molecules. The measured electrophoretic mobility for λ-DNA is only 20\% slower than previously measured on a flat Si wafer. This indicates that the separation mechanism is due to surface friction rather than biased reptation as reported by Tinland in the three dimensional Silica bead matrix where the mobility is two orders of magnitude smaller.",

author = "Seo, \{Y. S.\} and Samuilov, \{V. A.\} and J. Sokolov and M. Rafailovich and D. Gersappe and B. Chu",

year = "2001",

language = "English",

volume = "636",

pages = "D371--D375",

journal = "Materials Research Society Symposium - Proceedings",

issn = "0272-9172",

note = "Nonlithigraphic and Lithographic Methods of Nanofabrication -From Ultralarge-Scale Integration to Photonics to Molecular Electronics ; Conference date: 26-11-2000 Through 01-12-2000",

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TY - JOUR

T1 - DNA electrophoresis on two-dimensional arrays of SiO2 beads

AU - Seo, Y. S.

AU - Samuilov, V. A.

AU - Sokolov, J.

AU - Rafailovich, M.

AU - Gersappe, D.

AU - Chu, B.

PY - 2001

Y1 - 2001

N2 - A novel approach of fabricating 2-D arrays of SiO2 beads on a Si surface using the Langmuir-Blodgett (LB) technique is reported. The corrugated surfaces were tested as a separation media for surface electrophoresis of DNA molecules. The measured electrophoretic mobility for λ-DNA is only 20% slower than previously measured on a flat Si wafer. This indicates that the separation mechanism is due to surface friction rather than biased reptation as reported by Tinland in the three dimensional Silica bead matrix where the mobility is two orders of magnitude smaller.

AB - A novel approach of fabricating 2-D arrays of SiO2 beads on a Si surface using the Langmuir-Blodgett (LB) technique is reported. The corrugated surfaces were tested as a separation media for surface electrophoresis of DNA molecules. The measured electrophoretic mobility for λ-DNA is only 20% slower than previously measured on a flat Si wafer. This indicates that the separation mechanism is due to surface friction rather than biased reptation as reported by Tinland in the three dimensional Silica bead matrix where the mobility is two orders of magnitude smaller.

UR - https://www.scopus.com/pages/publications/0034818444

M3 - Conference article

SN - 0272-9172

VL - 636

SP - D371-D375

JO - Materials Research Society Symposium - Proceedings

JF - Materials Research Society Symposium - Proceedings

T2 - Nonlithigraphic and Lithographic Methods of Nanofabrication -From Ultralarge-Scale Integration to Photonics to Molecular Electronics

Y2 - 26 November 2000 through 1 December 2000

ER -

DNA electrophoresis on two-dimensional arrays of SiO₂ beads

Abstract

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