Dopamine D4 receptor (D4R) deletion in mice does not affect operant responding for food or cocaine

Panayotis K. Thanos; Rahila Habibi; Michael Michaelides; Ujval B. Patel; Katherine Suchland; Brenda J. Anderson; John K. Robinson; Gene Jack Wang; David K. Grandy; Nora D. Volkow

doi:10.1016/j.bbr.2009.10.020

Dopamine D4 receptor (D4R) deletion in mice does not affect operant responding for food or cocaine

Panayotis K. Thanos
, Rahila Habibi
, Michael Michaelides
, Ujval B. Patel
, Katherine Suchland
, Brenda J. Anderson
, John K. Robinson
, Gene Jack Wang
, David K. Grandy
, Nora D. Volkow

University at Buffalo, Stony Brook University

Brookhaven National Laboratory
Stony Brook University
Oregon Health and Science University
National Institutes of Health
Stony Brook University

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

In this study we examined the genetic contribution of the D4R in food and cocaine self-administration using D4R mice. Mice were examined for operant responding to food pellets or intravenous cocaine. Compared to wild-type mice (D4R^+/+), both heterozygous (D4R^+/-) and knockout (D4R^-/-) mice showed no difference in responding for food or cocaine. Our findings suggest that the D4R is not directly involved in mediating operant response behaviors for food or cocaine.

Original language	English
Pages (from-to)	508-511
Number of pages	4
Journal	Behavioural Brain Research
Volume	207
Issue number	2
DOIs	https://doi.org/10.1016/j.bbr.2009.10.020
State	Published - Mar 5 2010

Keywords

Addiction
Cognition
Reinforcement
Reward

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10.1016/j.bbr.2009.10.020

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title = "Dopamine D4 receptor (D4R) deletion in mice does not affect operant responding for food or cocaine",

abstract = "In this study we examined the genetic contribution of the D4R in food and cocaine self-administration using D4R mice. Mice were examined for operant responding to food pellets or intravenous cocaine. Compared to wild-type mice (D4R+/+), both heterozygous (D4R+/-) and knockout (D4R-/-) mice showed no difference in responding for food or cocaine. Our findings suggest that the D4R is not directly involved in mediating operant response behaviors for food or cocaine.",

keywords = "Addiction, Cognition, Reinforcement, Reward",

author = "Thanos, \{Panayotis K.\} and Rahila Habibi and Michael Michaelides and Patel, \{Ujval B.\} and Katherine Suchland and Anderson, \{Brenda J.\} and Robinson, \{John K.\} and Wang, \{Gene Jack\} and Grandy, \{David K.\} and Volkow, \{Nora D.\}",

year = "2010",

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doi = "10.1016/j.bbr.2009.10.020",

language = "English",

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pages = "508--511",

journal = "Behavioural Brain Research",

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TY - JOUR

T1 - Dopamine D4 receptor (D4R) deletion in mice does not affect operant responding for food or cocaine

AU - Thanos, Panayotis K.

AU - Habibi, Rahila

AU - Michaelides, Michael

AU - Patel, Ujval B.

AU - Suchland, Katherine

AU - Anderson, Brenda J.

AU - Robinson, John K.

AU - Wang, Gene Jack

AU - Grandy, David K.

AU - Volkow, Nora D.

PY - 2010/3/5

Y1 - 2010/3/5

N2 - In this study we examined the genetic contribution of the D4R in food and cocaine self-administration using D4R mice. Mice were examined for operant responding to food pellets or intravenous cocaine. Compared to wild-type mice (D4R+/+), both heterozygous (D4R+/-) and knockout (D4R-/-) mice showed no difference in responding for food or cocaine. Our findings suggest that the D4R is not directly involved in mediating operant response behaviors for food or cocaine.

AB - In this study we examined the genetic contribution of the D4R in food and cocaine self-administration using D4R mice. Mice were examined for operant responding to food pellets or intravenous cocaine. Compared to wild-type mice (D4R+/+), both heterozygous (D4R+/-) and knockout (D4R-/-) mice showed no difference in responding for food or cocaine. Our findings suggest that the D4R is not directly involved in mediating operant response behaviors for food or cocaine.

KW - Addiction

KW - Cognition

KW - Reinforcement

KW - Reward

UR - https://www.scopus.com/pages/publications/74449089290

U2 - 10.1016/j.bbr.2009.10.020

DO - 10.1016/j.bbr.2009.10.020

M3 - Article

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SN - 0166-4328

VL - 207

SP - 508

EP - 511

JO - Behavioural Brain Research

JF - Behavioural Brain Research

IS - 2

ER -

Dopamine D4 receptor (D4R) deletion in mice does not affect operant responding for food or cocaine

Abstract

Keywords

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