(E)-5-(3-oxopropen-1-yl)-2′-deoxyuridine and (E)-5-(3-oxopropen-1-yl)-2′,3′-dideoxyuridine; new antiviral agents: Syntheses and biological activity

Young Moon Cho; Francis Johnson

doi:10.1016/0040-4039(94)88009-3

(E)-5-(3-oxopropen-1-yl)-2′-deoxyuridine and (E)-5-(3-oxopropen-1-yl)-2′,3′-dideoxyuridine; new antiviral agents: Syntheses and biological activity

Young Moon Cho
, Francis Johnson

Pharmacological Sciences

Stony Brook University

Stony Brook University

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

The synthese of the 5-(3-oxopropen-1-yl) derivatives of dU (5) and ddU (6) and their biological activity are reported. Good antiviral activity (EC₅₀, 1.4 μg/mL) and selectivity (SI > 71.4) is shown by 5 against VZV, whereas in the case of 6 the antiviral activity (EC₅₀, 2.6 μg/mL; SI > 38.5) against EBV is greater than that of Acyclovir (EC₅₀, 9.3 μg/mL).

Original language	English
Pages (from-to)	1149-1152
Number of pages	4
Journal	Tetrahedron Letters
Volume	35
Issue number	8
DOIs	https://doi.org/10.1016/0040-4039(94)88009-3
State	Published - Feb 21 1994

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@article{4a8a7c8329a445ffba4c3d82c9a58499,

title = "(E)-5-(3-oxopropen-1-yl)-2′-deoxyuridine and (E)-5-(3-oxopropen-1-yl)-2′,3′-dideoxyuridine; new antiviral agents: Syntheses and biological activity",

abstract = "The synthese of the 5-(3-oxopropen-1-yl) derivatives of dU (5) and ddU (6) and their biological activity are reported. Good antiviral activity (EC50, 1.4 μg/mL) and selectivity (SI > 71.4) is shown by 5 against VZV, whereas in the case of 6 the antiviral activity (EC50, 2.6 μg/mL; SI > 38.5) against EBV is greater than that of Acyclovir (EC50, 9.3 μg/mL).",

author = "Cho, \{Young Moon\} and Francis Johnson",

year = "1994",

month = feb,

day = "21",

doi = "10.1016/0040-4039(94)88009-3",

language = "English",

volume = "35",

pages = "1149--1152",

journal = "Tetrahedron Letters",

issn = "0040-4039",

number = "8",

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TY - JOUR

T1 - (E)-5-(3-oxopropen-1-yl)-2′-deoxyuridine and (E)-5-(3-oxopropen-1-yl)-2′,3′-dideoxyuridine; new antiviral agents

T2 - Syntheses and biological activity

AU - Cho, Young Moon

AU - Johnson, Francis

PY - 1994/2/21

Y1 - 1994/2/21

N2 - The synthese of the 5-(3-oxopropen-1-yl) derivatives of dU (5) and ddU (6) and their biological activity are reported. Good antiviral activity (EC50, 1.4 μg/mL) and selectivity (SI > 71.4) is shown by 5 against VZV, whereas in the case of 6 the antiviral activity (EC50, 2.6 μg/mL; SI > 38.5) against EBV is greater than that of Acyclovir (EC50, 9.3 μg/mL).

AB - The synthese of the 5-(3-oxopropen-1-yl) derivatives of dU (5) and ddU (6) and their biological activity are reported. Good antiviral activity (EC50, 1.4 μg/mL) and selectivity (SI > 71.4) is shown by 5 against VZV, whereas in the case of 6 the antiviral activity (EC50, 2.6 μg/mL; SI > 38.5) against EBV is greater than that of Acyclovir (EC50, 9.3 μg/mL).

UR - https://www.scopus.com/pages/publications/0028331422

U2 - 10.1016/0040-4039(94)88009-3

DO - 10.1016/0040-4039(94)88009-3

M3 - Article

SN - 0040-4039

VL - 35

SP - 1149

EP - 1152

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 8

ER -

(E)-5-(3-oxopropen-1-yl)-2′-deoxyuridine and (E)-5-(3-oxopropen-1-yl)-2′,3′-dideoxyuridine; new antiviral agents: Syntheses and biological activity

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