Abstract
The effects of lead on long-term potentiation (LTP) in the hippocampal area CA3 were different in 30-day (P30) and 60-day-old (P60) rats upon either acute perfusion of lead to the isolated brain slice from controls or when recorded from slices from rats after chronic developmental exposure to lead. Lead caused a significant inhibition of LTP in 30-day CA3, and a significant potentiation in 60-day CA3 with either exposure paradigm. Consistent with the effects on LTP, lead inhibits phorbol ester-induced synaptic potentiation in 30-day rats and enhances phorbol ester-induced potentiation in 60-day rats. Protein kinase C (PKC) has been implicated in actions of lead but previous investigations have reported either a stimulation or a blockade of PKC by lead. Our results are consistent with the hypothesis that the effects of lead on LTP are mediated via an action on PKC, which varies with age. Theme: Excitable membranes and synaptic transmission. Topic: Long-term potentiation: pharmacology. Copyright (C) 2000 Elsevier Science B.V.
| Original language | English |
|---|---|
| Pages (from-to) | 243-252 |
| Number of pages | 10 |
| Journal | Developmental Brain Research |
| Volume | 121 |
| Issue number | 2 |
| DOIs | |
| State | Published - Jun 30 2000 |
Keywords
- Lead
- Mossy fiber-CA3
- Protein kinase C
- Synaptic plasticity
Fingerprint
Dive into the research topics of 'Effects of lead on long-term potentiation in hippocampal CA3 vary with age'. Together they form a unique fingerprint.Cite this
- APA
- Author
- BIBTEX
- Harvard
- Standard
- RIS
- Vancouver