TY - JOUR
T1 - Effects of schistosomes on host anti-viral immune response and the acquisition, virulence, and prevention of viral infections
T2 - A systematic review
AU - Bullington, Brooke W.
AU - Klemperer, Katherine
AU - Mages, Keith
AU - Chalem, Andrea
AU - Mazigo, Humphrey D.
AU - Changalucha, John
AU - Kapiga, Saidi
AU - Wright, Peter F.
AU - Yazdanbakhsh, Maria M.
AU - Downs, Jennifer A.
N1 - Publisher Copyright: Copyright: © 2021 Bullington et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
PY - 2021/5
Y1 - 2021/5
N2 - Although a growing number of studies suggest interactions between Schistosoma parasites and viral infections, the effects of schistosome infections on the host response to viruses have not been evaluated comprehensively. In this systematic review, we investigated how schistosomes impact incidence, virulence, and prevention of viral infections in humans and animals. We also evaluated immune effects of schistosomes in those coinfected with viruses. We screened 4,730 studies and included 103. Schistosomes may increase susceptibility to some viruses, including HIV and Kaposi’s sarcoma-associated herpesvirus, and virulence of hepatitis B and C viruses. In contrast, schistosome infection may be protective in chronic HIV, Human T-cell Lymphotropic Virus-Type 1, and respiratory viruses, though further research is needed. Schistosome infections were consistently reported to impair immune responses to hepatitis B and possibly measles vaccines. Understanding the interplay between schistosomes and viruses has ramifications for anti-viral vaccination strategies and global control of viral infections.
AB - Although a growing number of studies suggest interactions between Schistosoma parasites and viral infections, the effects of schistosome infections on the host response to viruses have not been evaluated comprehensively. In this systematic review, we investigated how schistosomes impact incidence, virulence, and prevention of viral infections in humans and animals. We also evaluated immune effects of schistosomes in those coinfected with viruses. We screened 4,730 studies and included 103. Schistosomes may increase susceptibility to some viruses, including HIV and Kaposi’s sarcoma-associated herpesvirus, and virulence of hepatitis B and C viruses. In contrast, schistosome infection may be protective in chronic HIV, Human T-cell Lymphotropic Virus-Type 1, and respiratory viruses, though further research is needed. Schistosome infections were consistently reported to impair immune responses to hepatitis B and possibly measles vaccines. Understanding the interplay between schistosomes and viruses has ramifications for anti-viral vaccination strategies and global control of viral infections.
UR - https://www.scopus.com/pages/publications/85106531359
U2 - 10.1371/journal.ppat.1009555
DO - 10.1371/journal.ppat.1009555
M3 - Review article
C2 - 34015063
SN - 1553-7366
VL - 17
JO - PLOS Pathogens
JF - PLOS Pathogens
IS - 5
M1 - e1009555
ER -