Emerging roles of the Th17/IL-17-axis in glomerulonephritis

Kritika Ramani; Partha S. Biswas

doi:10.1016/j.cyto.2015.07.029

Emerging roles of the Th17/IL-17-axis in glomerulonephritis

Kritika Ramani
, Partha S. Biswas

Microbiology and Immunology

Stony Brook University

University of Pittsburgh

Research output: Contribution to journal › Review article › peer-review

15 Scopus citations

Abstract

Different T cell subsets have been implicated in the pathogenesis of glomerulonephritis. Several lines of evidence indicate the recently identified interleukin-17 (IL-17)-producing T cells (Th17 cells) to be involved in the renal inflammatory cascade associated with glomerulonephritis. In this review we outline different forms of glomerulonephritis and the contribution of the Th17/IL-17-axis in mediating the downstream effects and pathology associated with the disease. Learning more about the Th17/IL-17-axis can help to develop promising therapeutic strategy for the treatment of various forms of glomerulonephritis.

Original language	English
Pages (from-to)	238-244
Number of pages	7
Journal	Cytokine
Volume	77
DOIs	https://doi.org/10.1016/j.cyto.2015.07.029
State	Published - Jan 1 2016

Keywords

Glomerulonephritis
IL-17
T-helper 17

Access to Document

10.1016/j.cyto.2015.07.029

Cite this

@article{a66491384ca54724bb89b1c8fa3a5aba,

title = "Emerging roles of the Th17/IL-17-axis in glomerulonephritis",

abstract = "Different T cell subsets have been implicated in the pathogenesis of glomerulonephritis. Several lines of evidence indicate the recently identified interleukin-17 (IL-17)-producing T cells (Th17 cells) to be involved in the renal inflammatory cascade associated with glomerulonephritis. In this review we outline different forms of glomerulonephritis and the contribution of the Th17/IL-17-axis in mediating the downstream effects and pathology associated with the disease. Learning more about the Th17/IL-17-axis can help to develop promising therapeutic strategy for the treatment of various forms of glomerulonephritis.",

keywords = "Glomerulonephritis, IL-17, T-helper 17",

author = "Kritika Ramani and Biswas, \{Partha S.\}",

note = "Publisher Copyright: {\textcopyright} 2015 Elsevier Ltd.",

year = "2016",

month = jan,

day = "1",

doi = "10.1016/j.cyto.2015.07.029",

language = "English",

volume = "77",

pages = "238--244",

journal = "Cytokine",

issn = "1043-4666",

publisher = "Academic Press",

}

TY - JOUR

T1 - Emerging roles of the Th17/IL-17-axis in glomerulonephritis

AU - Ramani, Kritika

AU - Biswas, Partha S.

PY - 2016/1/1

Y1 - 2016/1/1

N2 - Different T cell subsets have been implicated in the pathogenesis of glomerulonephritis. Several lines of evidence indicate the recently identified interleukin-17 (IL-17)-producing T cells (Th17 cells) to be involved in the renal inflammatory cascade associated with glomerulonephritis. In this review we outline different forms of glomerulonephritis and the contribution of the Th17/IL-17-axis in mediating the downstream effects and pathology associated with the disease. Learning more about the Th17/IL-17-axis can help to develop promising therapeutic strategy for the treatment of various forms of glomerulonephritis.

AB - Different T cell subsets have been implicated in the pathogenesis of glomerulonephritis. Several lines of evidence indicate the recently identified interleukin-17 (IL-17)-producing T cells (Th17 cells) to be involved in the renal inflammatory cascade associated with glomerulonephritis. In this review we outline different forms of glomerulonephritis and the contribution of the Th17/IL-17-axis in mediating the downstream effects and pathology associated with the disease. Learning more about the Th17/IL-17-axis can help to develop promising therapeutic strategy for the treatment of various forms of glomerulonephritis.

KW - Glomerulonephritis

KW - IL-17

KW - T-helper 17

UR - https://www.scopus.com/pages/publications/84949106291

U2 - 10.1016/j.cyto.2015.07.029

DO - 10.1016/j.cyto.2015.07.029

M3 - Review article

C2 - 26440138

SN - 1043-4666

VL - 77

SP - 238

EP - 244

JO - Cytokine

JF - Cytokine

ER -

Emerging roles of the Th17/IL-17-axis in glomerulonephritis

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this