ENDOTHELIN IN THE CENTRAL NERVOUS SYSTEM

Robert N. Willette; Giora Z. Feuerstein; Frank C. Barone

doi:10.1201/9781003574637-7

ENDOTHELIN IN THE CENTRAL NERVOUS SYSTEM

Robert N. Willette
, Giora Z. Feuerstein
, Frank C. Barone

Neurology

SUNY Downstate Health Sciences University

Department of Cardiovascular Pharmacology

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

Abstract

The identification of endothelin from a porcine aortic endothelial cell culture and its description as a potent and long-acting vasoactive peptide¹²has been rapidly followed by the identification of endothelin isoforms (endothelin-1, endothelin-2, and endothelin-3) and receptor subtypes (ET_A, ET_B1, and ET_B2). In the brain, the presence the endothelin isopeptides and receptor subtypes has been established in various cell types, including neurons, glia, vascular smooth muscle, and endothelium.³⁴ Consequently, endothelin is no longer viewed strictly as an endothelium-derived peptide. Recent studies suggest that endothelin may exert vascular, paracrine, neuromodulatory, neuroendocrine, and trophic effects in the central nervous system (CNS).

Original language	English
Title of host publication	Endothelin Receptors
Subtitle of host publication	from the Gene to the Human
Publisher	CRC Press
Pages	187-213
Number of pages	27
ISBN (Electronic)	9781040293713
ISBN (Print)	9780849359385
DOIs	https://doi.org/10.1201/9781003574637-7
State	Published - Jan 1 2024

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title = "ENDOTHELIN IN THE CENTRAL NERVOUS SYSTEM",

abstract = "The identification of endothelin from a porcine aortic endothelial cell culture and its description as a potent and long-acting vasoactive peptide12has been rapidly followed by the identification of endothelin isoforms (endothelin-1, endothelin-2, and endothelin-3) and receptor subtypes (ETA, ETB1, and ETB2). In the brain, the presence the endothelin isopeptides and receptor subtypes has been established in various cell types, including neurons, glia, vascular smooth muscle, and endothelium.34 Consequently, endothelin is no longer viewed strictly as an endothelium-derived peptide. Recent studies suggest that endothelin may exert vascular, paracrine, neuromodulatory, neuroendocrine, and trophic effects in the central nervous system (CNS).",

author = "Willette, \{Robert N.\} and Feuerstein, \{Giora Z.\} and Barone, \{Frank C.\}",

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AU - Feuerstein, Giora Z.

AU - Barone, Frank C.

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N2 - The identification of endothelin from a porcine aortic endothelial cell culture and its description as a potent and long-acting vasoactive peptide12has been rapidly followed by the identification of endothelin isoforms (endothelin-1, endothelin-2, and endothelin-3) and receptor subtypes (ETA, ETB1, and ETB2). In the brain, the presence the endothelin isopeptides and receptor subtypes has been established in various cell types, including neurons, glia, vascular smooth muscle, and endothelium.34 Consequently, endothelin is no longer viewed strictly as an endothelium-derived peptide. Recent studies suggest that endothelin may exert vascular, paracrine, neuromodulatory, neuroendocrine, and trophic effects in the central nervous system (CNS).

AB - The identification of endothelin from a porcine aortic endothelial cell culture and its description as a potent and long-acting vasoactive peptide12has been rapidly followed by the identification of endothelin isoforms (endothelin-1, endothelin-2, and endothelin-3) and receptor subtypes (ETA, ETB1, and ETB2). In the brain, the presence the endothelin isopeptides and receptor subtypes has been established in various cell types, including neurons, glia, vascular smooth muscle, and endothelium.34 Consequently, endothelin is no longer viewed strictly as an endothelium-derived peptide. Recent studies suggest that endothelin may exert vascular, paracrine, neuromodulatory, neuroendocrine, and trophic effects in the central nervous system (CNS).

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BT - Endothelin Receptors

PB - CRC Press

ER -

ENDOTHELIN IN THE CENTRAL NERVOUS SYSTEM

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