Enhanced efflux pump activity in old candida glabrata cells

Somanon Bhattacharya; Bettina C. Friesa

doi:10.1128/AAC.02227-17

Enhanced efflux pump activity in old candida glabrata cells

Somanon Bhattacharya
, Bettina C. Friesa

Infectious Diseases

Stony Brook University

Stony Brook University

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

We investigated the effect of replicative aging on antifungal resistance in Candida glabrata. Our studies demonstrate significantly increased transcription of ABC transporters and efflux pump activity in old versus young C. glabrata cells of a fluconazole-sensitive and -resistant strain. In addition, higher tolerance to killing by micafungin and amphotericin B was noted and is associated with higher transcription of glucan synthase gene FKS1 and lower ergosterol content in older cells.

Original language	English
Article number	e02227-17
Journal	Antimicrobial Agents and Chemotherapy
Volume	62
Issue number	3
DOIs	https://doi.org/10.1128/AAC.02227-17
State	Published - Mar 2018

Keywords

Aging
Antifungal resistance
Candida glabrata
Drug resistance mechanisms
Efflux pumps

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10.1128/AAC.02227-17

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abstract = "We investigated the effect of replicative aging on antifungal resistance in Candida glabrata. Our studies demonstrate significantly increased transcription of ABC transporters and efflux pump activity in old versus young C. glabrata cells of a fluconazole-sensitive and -resistant strain. In addition, higher tolerance to killing by micafungin and amphotericin B was noted and is associated with higher transcription of glucan synthase gene FKS1 and lower ergosterol content in older cells.",

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AB - We investigated the effect of replicative aging on antifungal resistance in Candida glabrata. Our studies demonstrate significantly increased transcription of ABC transporters and efflux pump activity in old versus young C. glabrata cells of a fluconazole-sensitive and -resistant strain. In addition, higher tolerance to killing by micafungin and amphotericin B was noted and is associated with higher transcription of glucan synthase gene FKS1 and lower ergosterol content in older cells.

KW - Aging

KW - Antifungal resistance

KW - Candida glabrata

KW - Drug resistance mechanisms

KW - Efflux pumps

UR - https://www.scopus.com/pages/publications/85042368606

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DO - 10.1128/AAC.02227-17

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ER -

Enhanced efflux pump activity in old candida glabrata cells

Abstract

Keywords

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