Abstract
Currently, and globally, we are facing the worst epidemic of psychoactive drug abuse resulting in the loss of hundreds of thousands of lives annually. Besides alcohol and opioid use and misuse, there has been an increase in illicit abuse of psychostimulants. Epigenetics is a relatively novel area of research that studies herita-ble alterations in gene expression. Long-term administration of psychoactive drugs may lead to transcriptional changes in brain regions related to drug-seeking behaviors and rewards that can be passed down transgeneratio-nally. Epigenetic biomarkers such as DNA methylation and histone modifications contribute to disease diagnos-es. This review aims to look at the epigenetic modifications brought forth by psychoactive drug abuse.
| Original language | English |
|---|---|
| Pages (from-to) | 2124-2139 |
| Number of pages | 16 |
| Journal | Current Pharmaceutical Design |
| Volume | 29 |
| Issue number | 27 |
| DOIs | |
| State | Published - 2023 |
Keywords
- DNA methylation
- Epigenetics
- epigenetic biomarkers
- histone modifications
- psychoactive drugs
- transgenerational
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