Evaluation and development of gas chromatographic procedures for the determination of γ-hydroxybutyric acid and γ-butyrolactone in plasma

John T. Lettieri; Ho Leung Fung

doi:10.1016/0006-2944(78)90051-0

Evaluation and development of gas chromatographic procedures for the determination of γ-hydroxybutyric acid and γ-butyrolactone in plasma

John T. Lettieri
, Ho Leung Fung

Pharmaceutical Sciences

University at Buffalo

SUNY Buffalo

Research output: Contribution to journal › Article › peer-review

48 Scopus citations

Abstract

The available methods of analysis for GHB and GBL were examined, and a modified gas chromatographic procedure was developed which improved upon the recovery of drug from plasma. It was shown also that the literature method which claimed to be a differential assay for GBL and GHB is not specific. Thus, previous reports describing intact GBL levels might not be reliable.

Original language	English
Pages (from-to)	70-80
Number of pages	11
Journal	Biochemical Medicine
Volume	20
Issue number	1
DOIs	https://doi.org/10.1016/0006-2944(78)90051-0
State	Published - Aug 1978

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10.1016/0006-2944(78)90051-0

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title = "Evaluation and development of gas chromatographic procedures for the determination of γ-hydroxybutyric acid and γ-butyrolactone in plasma",

abstract = "The available methods of analysis for GHB and GBL were examined, and a modified gas chromatographic procedure was developed which improved upon the recovery of drug from plasma. It was shown also that the literature method which claimed to be a differential assay for GBL and GHB is not specific. Thus, previous reports describing intact GBL levels might not be reliable.",

author = "Lettieri, \{John T.\} and Fung, \{Ho Leung\}",

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AU - Fung, Ho Leung

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Y1 - 1978/8

N2 - The available methods of analysis for GHB and GBL were examined, and a modified gas chromatographic procedure was developed which improved upon the recovery of drug from plasma. It was shown also that the literature method which claimed to be a differential assay for GBL and GHB is not specific. Thus, previous reports describing intact GBL levels might not be reliable.

AB - The available methods of analysis for GHB and GBL were examined, and a modified gas chromatographic procedure was developed which improved upon the recovery of drug from plasma. It was shown also that the literature method which claimed to be a differential assay for GBL and GHB is not specific. Thus, previous reports describing intact GBL levels might not be reliable.

UR - https://www.scopus.com/pages/publications/0018186408

U2 - 10.1016/0006-2944(78)90051-0

DO - 10.1016/0006-2944(78)90051-0

M3 - Article

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JO - Biochemical Medicine

JF - Biochemical Medicine

IS - 1

ER -

Evaluation and development of gas chromatographic procedures for the determination of γ-hydroxybutyric acid and γ-butyrolactone in plasma

Abstract

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