Evolutionary scenario for acquisition of CAG repeats in human SCA1 gene

Tatsuaki Kurosaki; Aya Ninokata; Li Wang; Shintaroh Ueda

doi:10.1016/j.gene.2005.12.017

Evolutionary scenario for acquisition of CAG repeats in human SCA1 gene

Tatsuaki Kurosaki
, Aya Ninokata
, Li Wang
, Shintaroh Ueda

Biotechnical and Clinical Laboratory Sciences

University at Buffalo

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

We investigated the CAG repeat sequence of the spinocerebellar ataxia type 1 (SCA1) gene in various species of primates to reveal how human has acquired the repeat structure with interruptions. Our results demonstrate no repetitive structure in the region corresponding to the human CAG repeats in prosimians and New World monkeys like in rodents, perfect (uninterrupted) CAG repeats in Old World monkeys, and interrupted CAG repeats in hominoids. Comparative analysis on the secondary structures of the primate SCA1 transcripts suggests the human prototype was built in the common ancestor of simians. We show an evolutionary scenario for acquisition of CAG repeats with interruptions in the human SCA1 gene.

Original language	English
Pages (from-to)	23-27
Number of pages	5
Journal	Gene
Volume	373
Issue number	1-2
DOIs	https://doi.org/10.1016/j.gene.2005.12.017
State	Published - May 24 2006

Keywords

Glutamine repeat
Primate
SCA1
Spinocerebellar ataxia

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10.1016/j.gene.2005.12.017

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abstract = "We investigated the CAG repeat sequence of the spinocerebellar ataxia type 1 (SCA1) gene in various species of primates to reveal how human has acquired the repeat structure with interruptions. Our results demonstrate no repetitive structure in the region corresponding to the human CAG repeats in prosimians and New World monkeys like in rodents, perfect (uninterrupted) CAG repeats in Old World monkeys, and interrupted CAG repeats in hominoids. Comparative analysis on the secondary structures of the primate SCA1 transcripts suggests the human prototype was built in the common ancestor of simians. We show an evolutionary scenario for acquisition of CAG repeats with interruptions in the human SCA1 gene.",

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AU - Ninokata, Aya

AU - Wang, Li

AU - Ueda, Shintaroh

PY - 2006/5/24

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N2 - We investigated the CAG repeat sequence of the spinocerebellar ataxia type 1 (SCA1) gene in various species of primates to reveal how human has acquired the repeat structure with interruptions. Our results demonstrate no repetitive structure in the region corresponding to the human CAG repeats in prosimians and New World monkeys like in rodents, perfect (uninterrupted) CAG repeats in Old World monkeys, and interrupted CAG repeats in hominoids. Comparative analysis on the secondary structures of the primate SCA1 transcripts suggests the human prototype was built in the common ancestor of simians. We show an evolutionary scenario for acquisition of CAG repeats with interruptions in the human SCA1 gene.

AB - We investigated the CAG repeat sequence of the spinocerebellar ataxia type 1 (SCA1) gene in various species of primates to reveal how human has acquired the repeat structure with interruptions. Our results demonstrate no repetitive structure in the region corresponding to the human CAG repeats in prosimians and New World monkeys like in rodents, perfect (uninterrupted) CAG repeats in Old World monkeys, and interrupted CAG repeats in hominoids. Comparative analysis on the secondary structures of the primate SCA1 transcripts suggests the human prototype was built in the common ancestor of simians. We show an evolutionary scenario for acquisition of CAG repeats with interruptions in the human SCA1 gene.

KW - Glutamine repeat

KW - Primate

KW - SCA1

KW - Spinocerebellar ataxia

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DO - 10.1016/j.gene.2005.12.017

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VL - 373

SP - 23

EP - 27

JO - Gene

JF - Gene

IS - 1-2

ER -

Evolutionary scenario for acquisition of CAG repeats in human SCA1 gene

Abstract

Keywords

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