Fatigue Impacts Quality of Life in People with Spinocerebellar Ataxias

Ruo Yah Lai; Christian Rummey; Christian J. Amlang; Chi Ying R. Lin; Tiffany X. Chen; Susan Perlman; George Wilmot; Christopher M. Gomez; Jeremy D. Schmahmann; Henry Paulson; Sarah H. Ying; Chiadi U. Onyike; Theresa A. Zesiewicz; Khalaf O. Bushara; Michael D. Geschwind; Karla P. Figueroa; Stefan M. Pulst; Sub H. Subramony; Matthew R. Burns; Puneet Opal; Antoine Duquette; Tetsuo Ashizawa; Ali G. Hamedani; Marie Y. Davis; Sharan R. Srinivasan; Lauren R. Moore; Vikram G. Shakkottai; Liana S. Rosenthal; Sheng Han Kuo

doi:10.1002/mdc3.14006

Fatigue Impacts Quality of Life in People with Spinocerebellar Ataxias

Ruo Yah Lai
, Christian Rummey
, Christian J. Amlang
, Chi Ying R. Lin
, Tiffany X. Chen
, Susan Perlman
, George Wilmot
, Christopher M. Gomez
, Jeremy D. Schmahmann
, Henry Paulson
, Sarah H. Ying
, Chiadi U. Onyike
, Theresa A. Zesiewicz
, Khalaf O. Bushara
, Michael D. Geschwind
, Karla P. Figueroa
, Stefan M. Pulst
, Sub H. Subramony
, Matthew R. Burns
, Puneet Opal

Antoine Duquette, Tetsuo Ashizawa, Ali G. Hamedani, Marie Y. Davis, Sharan R. Srinivasan, Lauren R. Moore, Vikram G. Shakkottai, Liana S. Rosenthal, Sheng Han Kuo

Neurology

SUNY Downstate Health Sciences University

Columbia University
Clinical Data Science GmbH
Baylor College of Medicine
Johns Hopkins University
University of California at Los Angeles
Emory University
The University of Chicago
Harvard University
University of Michigan, Ann Arbor
University of South Florida
University of Minnesota Twin Cities
University of California at San Francisco
University of Utah
University of Florida
Northwestern University
Centre Hospitalier de L'Universite de Montreal
Houston Methodist
University of Pennsylvania
University of Washington
VA Puget Sound Health Care System
National Ataxia Foundation
University of Texas Southwestern Medical Center

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

Background: Fatigue is a prevalent and debilitating symptom in neurological disorders, including spinocerebellar ataxias (SCAs). However, the risk factors of fatigue in the SCAs as well as its impact have not been well investigated. Objectives: To study the prevalence of fatigue in SCAs, the factors contributing to fatigue, and the influence of fatigue on quality of life. Methods: Fatigue was assessed in 418 participants with SCA1, SCA2, SCA3, and SCA6 from the Clinical Research Consortium for the Study of Cerebellar Ataxia using the Fatigue Severity Scale. We conducted multi-variable linear regression models to examine the factors contributing to fatigue as well as the association between fatigue and quality of life. Results: Fatigue was most prevalent in SCA3 (52.6%), followed by SCA1 (36.7%), SCA6 (35.7%), and SCA2 (35.6%). SCA cases with fatigue had more severe ataxia and worse depressive symptoms. In SCA3, those with fatigue had a longer disease duration and longer pathological CAG repeat numbers. In multi-variable models, depressive symptoms, but not ataxia severity, were associated with more severe fatigue. Fatigue, independent of ataxia and depression, contributed to worse quality of life in SCA3 and SCA6 at baseline, and fatigue continued affecting quality of life throughout the disease course in all types of SCA. Conclusions: Fatigue is a common symptom in SCAs and is closely related to depression. Fatigue significantly impacts patients' quality of life. Therefore, screening for fatigue should be considered a part of standard clinical care for SCAs.

Original language	English
Pages (from-to)	496-503
Number of pages	8
Journal	Movement Disorders Clinical Practice
Volume	11
Issue number	5
DOIs	https://doi.org/10.1002/mdc3.14006
State	Published - May 2024

Keywords

cerebellar ataxia
cerebellum
fatigue
quality of life
spinocerebellar ataxia

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10.1002/mdc3.14006

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Lai, R. Y., Rummey, C., Amlang, C. J., Lin, C. Y. R., Chen, T. X., Perlman, S., Wilmot, G., Gomez, C. M., Schmahmann, J. D., Paulson, H., Ying, S. H., Onyike, C. U., Zesiewicz, T. A., Bushara, K. O., Geschwind, M. D., Figueroa, K. P., Pulst, S. M., Subramony, S. H., Burns, M. R., ... Kuo, S. H. (2024). Fatigue Impacts Quality of Life in People with Spinocerebellar Ataxias. Movement Disorders Clinical Practice, 11(5), 496-503. https://doi.org/10.1002/mdc3.14006

@article{f027bafe37294128bd5f291d10845ccb,

title = "Fatigue Impacts Quality of Life in People with Spinocerebellar Ataxias",

abstract = "Background: Fatigue is a prevalent and debilitating symptom in neurological disorders, including spinocerebellar ataxias (SCAs). However, the risk factors of fatigue in the SCAs as well as its impact have not been well investigated. Objectives: To study the prevalence of fatigue in SCAs, the factors contributing to fatigue, and the influence of fatigue on quality of life. Methods: Fatigue was assessed in 418 participants with SCA1, SCA2, SCA3, and SCA6 from the Clinical Research Consortium for the Study of Cerebellar Ataxia using the Fatigue Severity Scale. We conducted multi-variable linear regression models to examine the factors contributing to fatigue as well as the association between fatigue and quality of life. Results: Fatigue was most prevalent in SCA3 (52.6\%), followed by SCA1 (36.7\%), SCA6 (35.7\%), and SCA2 (35.6\%). SCA cases with fatigue had more severe ataxia and worse depressive symptoms. In SCA3, those with fatigue had a longer disease duration and longer pathological CAG repeat numbers. In multi-variable models, depressive symptoms, but not ataxia severity, were associated with more severe fatigue. Fatigue, independent of ataxia and depression, contributed to worse quality of life in SCA3 and SCA6 at baseline, and fatigue continued affecting quality of life throughout the disease course in all types of SCA. Conclusions: Fatigue is a common symptom in SCAs and is closely related to depression. Fatigue significantly impacts patients' quality of life. Therefore, screening for fatigue should be considered a part of standard clinical care for SCAs.",

keywords = "cerebellar ataxia, cerebellum, fatigue, quality of life, spinocerebellar ataxia",

author = "Lai, \{Ruo Yah\} and Christian Rummey and Amlang, \{Christian J.\} and Lin, \{Chi Ying R.\} and Chen, \{Tiffany X.\} and Susan Perlman and George Wilmot and Gomez, \{Christopher M.\} and Schmahmann, \{Jeremy D.\} and Henry Paulson and Ying, \{Sarah H.\} and Onyike, \{Chiadi U.\} and Zesiewicz, \{Theresa A.\} and Bushara, \{Khalaf O.\} and Geschwind, \{Michael D.\} and Figueroa, \{Karla P.\} and Pulst, \{Stefan M.\} and Subramony, \{Sub H.\} and Burns, \{Matthew R.\} and Puneet Opal and Antoine Duquette and Tetsuo Ashizawa and Hamedani, \{Ali G.\} and Davis, \{Marie Y.\} and Srinivasan, \{Sharan R.\} and Moore, \{Lauren R.\} and Shakkottai, \{Vikram G.\} and Rosenthal, \{Liana S.\} and Kuo, \{Sheng Han\}",

note = "Publisher Copyright: {\textcopyright} 2024 International Parkinson and Movement Disorder Society.",

year = "2024",

month = may,

doi = "10.1002/mdc3.14006",

language = "English",

volume = "11",

pages = "496--503",

journal = "Movement Disorders Clinical Practice",

issn = "2330-1619",

publisher = "John Wiley and Sons Ltd",

number = "5",

}

Lai, RY, Rummey, C, Amlang, CJ, Lin, CYR, Chen, TX, Perlman, S, Wilmot, G, Gomez, CM, Schmahmann, JD, Paulson, H, Ying, SH, Onyike, CU, Zesiewicz, TA, Bushara, KO, Geschwind, MD, Figueroa, KP, Pulst, SM, Subramony, SH, Burns, MR, Opal, P, Duquette, A, Ashizawa, T, Hamedani, AG, Davis, MY, Srinivasan, SR, Moore, LR, Shakkottai, VG, Rosenthal, LS & Kuo, SH 2024, 'Fatigue Impacts Quality of Life in People with Spinocerebellar Ataxias', Movement Disorders Clinical Practice, vol. 11, no. 5, pp. 496-503. https://doi.org/10.1002/mdc3.14006

TY - JOUR

T1 - Fatigue Impacts Quality of Life in People with Spinocerebellar Ataxias

AU - Lai, Ruo Yah

AU - Rummey, Christian

AU - Amlang, Christian J.

AU - Lin, Chi Ying R.

AU - Chen, Tiffany X.

AU - Perlman, Susan

AU - Wilmot, George

AU - Gomez, Christopher M.

AU - Schmahmann, Jeremy D.

AU - Paulson, Henry

AU - Ying, Sarah H.

AU - Onyike, Chiadi U.

AU - Zesiewicz, Theresa A.

AU - Bushara, Khalaf O.

AU - Geschwind, Michael D.

AU - Figueroa, Karla P.

AU - Pulst, Stefan M.

AU - Subramony, Sub H.

AU - Burns, Matthew R.

AU - Opal, Puneet

AU - Duquette, Antoine

AU - Ashizawa, Tetsuo

AU - Hamedani, Ali G.

AU - Davis, Marie Y.

AU - Srinivasan, Sharan R.

AU - Moore, Lauren R.

AU - Shakkottai, Vikram G.

AU - Rosenthal, Liana S.

AU - Kuo, Sheng Han

PY - 2024/5

Y1 - 2024/5

N2 - Background: Fatigue is a prevalent and debilitating symptom in neurological disorders, including spinocerebellar ataxias (SCAs). However, the risk factors of fatigue in the SCAs as well as its impact have not been well investigated. Objectives: To study the prevalence of fatigue in SCAs, the factors contributing to fatigue, and the influence of fatigue on quality of life. Methods: Fatigue was assessed in 418 participants with SCA1, SCA2, SCA3, and SCA6 from the Clinical Research Consortium for the Study of Cerebellar Ataxia using the Fatigue Severity Scale. We conducted multi-variable linear regression models to examine the factors contributing to fatigue as well as the association between fatigue and quality of life. Results: Fatigue was most prevalent in SCA3 (52.6%), followed by SCA1 (36.7%), SCA6 (35.7%), and SCA2 (35.6%). SCA cases with fatigue had more severe ataxia and worse depressive symptoms. In SCA3, those with fatigue had a longer disease duration and longer pathological CAG repeat numbers. In multi-variable models, depressive symptoms, but not ataxia severity, were associated with more severe fatigue. Fatigue, independent of ataxia and depression, contributed to worse quality of life in SCA3 and SCA6 at baseline, and fatigue continued affecting quality of life throughout the disease course in all types of SCA. Conclusions: Fatigue is a common symptom in SCAs and is closely related to depression. Fatigue significantly impacts patients' quality of life. Therefore, screening for fatigue should be considered a part of standard clinical care for SCAs.

AB - Background: Fatigue is a prevalent and debilitating symptom in neurological disorders, including spinocerebellar ataxias (SCAs). However, the risk factors of fatigue in the SCAs as well as its impact have not been well investigated. Objectives: To study the prevalence of fatigue in SCAs, the factors contributing to fatigue, and the influence of fatigue on quality of life. Methods: Fatigue was assessed in 418 participants with SCA1, SCA2, SCA3, and SCA6 from the Clinical Research Consortium for the Study of Cerebellar Ataxia using the Fatigue Severity Scale. We conducted multi-variable linear regression models to examine the factors contributing to fatigue as well as the association between fatigue and quality of life. Results: Fatigue was most prevalent in SCA3 (52.6%), followed by SCA1 (36.7%), SCA6 (35.7%), and SCA2 (35.6%). SCA cases with fatigue had more severe ataxia and worse depressive symptoms. In SCA3, those with fatigue had a longer disease duration and longer pathological CAG repeat numbers. In multi-variable models, depressive symptoms, but not ataxia severity, were associated with more severe fatigue. Fatigue, independent of ataxia and depression, contributed to worse quality of life in SCA3 and SCA6 at baseline, and fatigue continued affecting quality of life throughout the disease course in all types of SCA. Conclusions: Fatigue is a common symptom in SCAs and is closely related to depression. Fatigue significantly impacts patients' quality of life. Therefore, screening for fatigue should be considered a part of standard clinical care for SCAs.

KW - cerebellar ataxia

KW - cerebellum

KW - fatigue

KW - quality of life

KW - spinocerebellar ataxia

UR - https://www.scopus.com/pages/publications/85186172225

U2 - 10.1002/mdc3.14006

DO - 10.1002/mdc3.14006

M3 - Article

SN - 2330-1619

VL - 11

SP - 496

EP - 503

JO - Movement Disorders Clinical Practice

JF - Movement Disorders Clinical Practice

IS - 5

ER -

Fatigue Impacts Quality of Life in People with Spinocerebellar Ataxias

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Keywords

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