Fetal environment, epigenetics, and pediatric renal disease

Robert Woroniecki; Anil Bhanudas Gaikwad; Katalin Susztak

doi:10.1007/s00467-010-1714-8

Fetal environment, epigenetics, and pediatric renal disease

Robert Woroniecki
, Anil Bhanudas Gaikwad
, Katalin Susztak

Pediatrics

Stony Brook University

Albert Einstein College of Medicine

Research output: Contribution to journal › Article › peer-review

43 Scopus citations

Abstract

The notion that some adult diseases may have their origins in utero has recently captured scientists' attention. Some of these effects persist across generations and may involve epigenetic mechanisms. Epigenetic modifications, DNA methylation together with covalent modifications of histones, alter chromatin density and accessibility of DNA to cellular machinery, modulating the transcriptional potential of the underlying DNA sequence. Here, we will discuss the different epigenetic modifications and their potential role in and contribution to renal disease development.

Original language	English
Pages (from-to)	705-711
Number of pages	7
Journal	Pediatric Nephrology
Volume	26
Issue number	5
DOIs	https://doi.org/10.1007/s00467-010-1714-8
State	Published - May 2011

Keywords

DNA methylation
Epigenetics
Histone modification
Intrauterine environment

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10.1007/s00467-010-1714-8

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abstract = "The notion that some adult diseases may have their origins in utero has recently captured scientists' attention. Some of these effects persist across generations and may involve epigenetic mechanisms. Epigenetic modifications, DNA methylation together with covalent modifications of histones, alter chromatin density and accessibility of DNA to cellular machinery, modulating the transcriptional potential of the underlying DNA sequence. Here, we will discuss the different epigenetic modifications and their potential role in and contribution to renal disease development.",

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KW - Epigenetics

KW - Histone modification

KW - Intrauterine environment

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Fetal environment, epigenetics, and pediatric renal disease

Abstract

Keywords

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