FGF Modulates the Axial Identity of Trunk hPSC-Derived Neural Crest but Not the Cranial-Trunk Decision

James O.S. Hackland; Patrick B. Shelar; Nabjot Sandhu; Maneeshi S. Prasad; Rebekah M. Charney; Gustavo A. Gomez; Thomas J.R. Frith; Martín I. García-Castro

doi:10.1016/j.stemcr.2019.04.015

FGF Modulates the Axial Identity of Trunk hPSC-Derived Neural Crest but Not the Cranial-Trunk Decision

James O.S. Hackland
, Patrick B. Shelar
, Nabjot Sandhu
, Maneeshi S. Prasad
, Rebekah M. Charney
, Gustavo A. Gomez
, Thomas J.R. Frith
, Martín I. García-Castro

Biochemistry

University at Buffalo

Research output: Contribution to journal › Article › peer-review

39 Scopus citations

Abstract

In this article, Hackland and colleagues present a highly efficient system for deriving trunk neural crest from hPSCs. They show using this system that FGF signaling dictates the axial identity of cells within the trunk compartment, but that the cranial versus trunk decision is FGF independent and is instead determined by the magnitude of WNT signaling.

Original language	English
Pages (from-to)	920-933
Number of pages	14
Journal	Stem Cell Reports
Volume	12
Issue number	5
DOIs	https://doi.org/10.1016/j.stemcr.2019.04.015
State	Published - May 14 2019

Keywords

Brachyury
CDX2
FGF
NMPs
OTX2
SOX2
WNT
axial progenitors
human pluripotent stemm cells
trunk neural crest

Access to Document

10.1016/j.stemcr.2019.04.015

Cite this

@article{380d1be69a2a4723b0952bd409177ac9,

title = "FGF Modulates the Axial Identity of Trunk hPSC-Derived Neural Crest but Not the Cranial-Trunk Decision",

abstract = "In this article, Hackland and colleagues present a highly efficient system for deriving trunk neural crest from hPSCs. They show using this system that FGF signaling dictates the axial identity of cells within the trunk compartment, but that the cranial versus trunk decision is FGF independent and is instead determined by the magnitude of WNT signaling.",

keywords = "Brachyury, CDX2, FGF, NMPs, OTX2, SOX2, WNT, axial progenitors, human pluripotent stemm cells, trunk neural crest",

author = "Hackland, \{James O.S.\} and Shelar, \{Patrick B.\} and Nabjot Sandhu and Prasad, \{Maneeshi S.\} and Charney, \{Rebekah M.\} and Gomez, \{Gustavo A.\} and Frith, \{Thomas J.R.\} and Garc{\'i}a-Castro, \{Mart{\'i}n I.\}",

note = "Publisher Copyright: {\textcopyright} 2019 The Authors",

year = "2019",

month = may,

day = "14",

doi = "10.1016/j.stemcr.2019.04.015",

language = "English",

volume = "12",

pages = "920--933",

journal = "Stem Cell Reports",

issn = "2213-6711",

publisher = "Cell Press",

number = "5",

}

TY - JOUR

T1 - FGF Modulates the Axial Identity of Trunk hPSC-Derived Neural Crest but Not the Cranial-Trunk Decision

AU - Hackland, James O.S.

AU - Shelar, Patrick B.

AU - Sandhu, Nabjot

AU - Prasad, Maneeshi S.

AU - Charney, Rebekah M.

AU - Gomez, Gustavo A.

AU - Frith, Thomas J.R.

AU - García-Castro, Martín I.

PY - 2019/5/14

Y1 - 2019/5/14

N2 - In this article, Hackland and colleagues present a highly efficient system for deriving trunk neural crest from hPSCs. They show using this system that FGF signaling dictates the axial identity of cells within the trunk compartment, but that the cranial versus trunk decision is FGF independent and is instead determined by the magnitude of WNT signaling.

AB - In this article, Hackland and colleagues present a highly efficient system for deriving trunk neural crest from hPSCs. They show using this system that FGF signaling dictates the axial identity of cells within the trunk compartment, but that the cranial versus trunk decision is FGF independent and is instead determined by the magnitude of WNT signaling.

KW - Brachyury

KW - CDX2

KW - FGF

KW - NMPs

KW - OTX2

KW - SOX2

KW - WNT

KW - axial progenitors

KW - human pluripotent stemm cells

KW - trunk neural crest

UR - https://www.scopus.com/pages/publications/85064767264

U2 - 10.1016/j.stemcr.2019.04.015

DO - 10.1016/j.stemcr.2019.04.015

M3 - Article

C2 - 31091435

SN - 2213-6711

VL - 12

SP - 920

EP - 933

JO - Stem Cell Reports

JF - Stem Cell Reports

IS - 5

ER -

FGF Modulates the Axial Identity of Trunk hPSC-Derived Neural Crest but Not the Cranial-Trunk Decision

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this