@inbook{4bb363d4b3364059b48b795c57d1e487,
title = "Fibrosis on a chip for screening of anti-fibrosis drugs",
abstract = "Idiopathic pulmonary fibrosis (IPF) is a chronic pathological disorder that targets alveoli interstitial tissues and is characterized by the progressive stiffening of alveolar membrane. The median survival rate of the patients with IPF is less than 5 years. Currently, IPF has no cure and there are few options to alleviate the progress of this disease. A critical roadblock in developing new anti-fibrosis therapies is the absence of reliable cell based in vitro models that can recapitulate the progressive features of this disease. Here a novel fibrotic microtissue on a chip system is created to model the fibrotic transition of the lung interstitial tissue and the effect of anti-fibrosis drugs on such transitions. This system will not only help to expedite the efficacy analysis of anti-fibrotic therapies but also help to unveil their potential mode of action.",
keywords = "Anti-fibrosis therapy, Drug screening, Lung on a chip, Microtissue array, Nintedanib, Pirfenidone, Pulmonary fibrosis, Stiffness, and contractile force, Tissue mechanics",
author = "Mohammadnabi Asmani and Ruogang Zhao",
note = "Publisher Copyright: {\textcopyright} Springer Science+Business Media, LLC, part of Springer Nature 2021.",
year = "2021",
doi = "10.1007/978-1-0716-1382-5\_19",
language = "English",
series = "Methods in Molecular Biology",
publisher = "Humana Press Inc.",
pages = "263--274",
booktitle = "Methods in Molecular Biology",
}