TY - GEN
T1 - Formal analysis of abnormal excitation in cardiac tissue
AU - Ye, Pei
AU - Grosu, Radu
AU - Smolka, Scott A.
AU - Entcheva, Emilia
PY - 2008
Y1 - 2008
N2 - We present the Piecewise Linear Approximation Model of Ion Channel contribution (PLAMIC) to cardiac excitation. We use the PLAMIC model to conduct formal analysis of cardiac arrhythmic events, namely Early Afterdepolarizations (EADs). The goal is to quantify (for the first time) the contribution of the overall sodium (Na∈+∈), potassium (K ∈+∈) and calcium (Ca2∈+∈) currents to the occurrence of EADs during the plateau phase of the cardiac action potential (AP). Our analysis yields exact mathematical criteria for the separation of the parameter space for normal and EAD-producing APs, which is validated by simulations with classical AP models based on complex systems of nonlinear differential equations. Our approach offers a simple formal technique for the prediction of conditions leading to arrhythmias (EADs) from a limited set of experimental measurements, and can be invaluable for devising new anti-arrhythmic strategies.
AB - We present the Piecewise Linear Approximation Model of Ion Channel contribution (PLAMIC) to cardiac excitation. We use the PLAMIC model to conduct formal analysis of cardiac arrhythmic events, namely Early Afterdepolarizations (EADs). The goal is to quantify (for the first time) the contribution of the overall sodium (Na∈+∈), potassium (K ∈+∈) and calcium (Ca2∈+∈) currents to the occurrence of EADs during the plateau phase of the cardiac action potential (AP). Our analysis yields exact mathematical criteria for the separation of the parameter space for normal and EAD-producing APs, which is validated by simulations with classical AP models based on complex systems of nonlinear differential equations. Our approach offers a simple formal technique for the prediction of conditions leading to arrhythmias (EADs) from a limited set of experimental measurements, and can be invaluable for devising new anti-arrhythmic strategies.
UR - https://www.scopus.com/pages/publications/57049187740
U2 - 10.1007/978-3-540-88562-7_13
DO - 10.1007/978-3-540-88562-7_13
M3 - Conference contribution
SN - 3540885617
SN - 9783540885610
T3 - Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
SP - 141
EP - 155
BT - Computational Methods in Systems Biology - 6th International Conference, CMSB 2008, Proceedings
T2 - 6th International Conference on Computational Methods in Systems Biology, CMSB 2008
Y2 - 12 October 2008 through 15 October 2008
ER -