Frizzled-4 C-terminus distal to KTXXXW motif is essential for normal dishevelled recruitment and norrin-stimulated activation of Lef/Tcf-dependent transcriptional activation

Alexander C. Bertalovitz; Milly S. Pau; Shujuan Gao; Craig C. Malbon; Hsien Yu Wang

doi:10.5334/1750-2187-11-1

Frizzled-4 C-terminus distal to KTXXXW motif is essential for normal dishevelled recruitment and norrin-stimulated activation of Lef/Tcf-dependent transcriptional activation

Alexander C. Bertalovitz
, Milly S. Pau
, Shujuan Gao
, Craig C. Malbon
, Hsien Yu Wang

Pharmacological Sciences

Stony Brook University

Stony Brook University

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

The carboxy (C)-termini of G protein coupled receptors (GPCR) dictate essential functions. The KTXXXW motif C-terminus of Frizzleds (FZD) has been implicated in recruitment of Dishevelled (DVL). Through study of FZD₄ and its associated ligand Norrin, we report that a minimum of three residues distal to the KTXXXW motif in the C-terminal tail of Frizzled-4 are essential for DVL recruitment and robust Lef/Tcf-dependent transcriptional activation in response to Norrin.

Original language	English
Pages (from-to)	1-7
Number of pages	7
Journal	Journal of Molecular Signaling
Volume	11
Issue number	1
DOIs	https://doi.org/10.5334/1750-2187-11-1
State	Published - 2016

Keywords

Carboxy-terminus
Dishevelled
Frizzled
Frizzled-4
Helix VIII
Norrin

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10.5334/1750-2187-11-1

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@article{d878f9895aa04e00b19ea98fb7052f50,

title = "Frizzled-4 C-terminus distal to KTXXXW motif is essential for normal dishevelled recruitment and norrin-stimulated activation of Lef/Tcf-dependent transcriptional activation",

abstract = "The carboxy (C)-termini of G protein coupled receptors (GPCR) dictate essential functions. The KTXXXW motif C-terminus of Frizzleds (FZD) has been implicated in recruitment of Dishevelled (DVL). Through study of FZD4 and its associated ligand Norrin, we report that a minimum of three residues distal to the KTXXXW motif in the C-terminal tail of Frizzled-4 are essential for DVL recruitment and robust Lef/Tcf-dependent transcriptional activation in response to Norrin.",

keywords = "Carboxy-terminus, Dishevelled, Frizzled, Frizzled-4, Helix VIII, Norrin",

author = "Bertalovitz, \{Alexander C.\} and Pau, \{Milly S.\} and Shujuan Gao and Malbon, \{Craig C.\} and Wang, \{Hsien Yu\}",

note = "Publisher Copyright: {\textcopyright} 2016 The Author(s).",

year = "2016",

doi = "10.5334/1750-2187-11-1",

language = "English",

volume = "11",

pages = "1--7",

journal = "Journal of Molecular Signaling",

issn = "1750-2187",

number = "1",

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Frizzled-4 C-terminus distal to KTXXXW motif is essential for normal dishevelled recruitment and norrin-stimulated activation of Lef/Tcf-dependent transcriptional activation. / Bertalovitz, Alexander C.; Pau, Milly S.; Gao, Shujuan et al.
In: Journal of Molecular Signaling, Vol. 11, No. 1, 2016, p. 1-7.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Frizzled-4 C-terminus distal to KTXXXW motif is essential for normal dishevelled recruitment and norrin-stimulated activation of Lef/Tcf-dependent transcriptional activation

AU - Bertalovitz, Alexander C.

AU - Pau, Milly S.

AU - Gao, Shujuan

AU - Malbon, Craig C.

AU - Wang, Hsien Yu

PY - 2016

Y1 - 2016

N2 - The carboxy (C)-termini of G protein coupled receptors (GPCR) dictate essential functions. The KTXXXW motif C-terminus of Frizzleds (FZD) has been implicated in recruitment of Dishevelled (DVL). Through study of FZD4 and its associated ligand Norrin, we report that a minimum of three residues distal to the KTXXXW motif in the C-terminal tail of Frizzled-4 are essential for DVL recruitment and robust Lef/Tcf-dependent transcriptional activation in response to Norrin.

AB - The carboxy (C)-termini of G protein coupled receptors (GPCR) dictate essential functions. The KTXXXW motif C-terminus of Frizzleds (FZD) has been implicated in recruitment of Dishevelled (DVL). Through study of FZD4 and its associated ligand Norrin, we report that a minimum of three residues distal to the KTXXXW motif in the C-terminal tail of Frizzled-4 are essential for DVL recruitment and robust Lef/Tcf-dependent transcriptional activation in response to Norrin.

KW - Carboxy-terminus

KW - Dishevelled

KW - Frizzled

KW - Frizzled-4

KW - Helix VIII

KW - Norrin

UR - https://www.scopus.com/pages/publications/85007422254

U2 - 10.5334/1750-2187-11-1

DO - 10.5334/1750-2187-11-1

M3 - Article

SN - 1750-2187

VL - 11

SP - 1

EP - 7

JO - Journal of Molecular Signaling

JF - Journal of Molecular Signaling

IS - 1

ER -

Frizzled-4 C-terminus distal to KTXXXW motif is essential for normal dishevelled recruitment and norrin-stimulated activation of Lef/Tcf-dependent transcriptional activation

Abstract

Keywords

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