Abstract
The use of ion‐pair extraction data to obtain group contribution values necessitates an assumption of counterion independency. This assumption was examined in the present study, using the extraction of four tricyclic antidepressants with several anions as examples. It was found to be valid, and a consistent relative functional group value could be obtained when substitution on the tricyclic amines was distant from the charged center. However, when substitution was at the charged center, as exemplified by comparison of the methylated and demethylated antidepressants, the observed group contribution value was anion dependent.
| Original language | English |
|---|---|
| Pages (from-to) | 1967-1970 |
| Number of pages | 4 |
| Journal | Journal of Pharmaceutical Sciences |
| Volume | 61 |
| Issue number | 12 |
| DOIs | |
| State | Published - Dec 1972 |
Keywords
- Counterion independency—interrelationship between ion‐pair extraction and group contribution, tricyclic amine antidepressants
- Functional group contribution in ion‐pair extraction—tricyclic amine antidepressants
- Ion‐pair extraction of tricyclic amine antidepressants—functional group contribution, linear free energy relationships
- Linear free energy relationships—tricyclic amine antidepressants
- Tricyclic amine antidepressants—ion‐pair extraction, functional group contribution, linear free energy relationships
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