GABA receptors, progesterone and premenstrual dysphoric disorder

Inger Sundström Poromaa; S. Smith; M. Gulinello

doi:10.1007/s00737-002-0147-1

GABA receptors, progesterone and premenstrual dysphoric disorder

Inger Sundström Poromaa
, S. Smith
, M. Gulinello

Physiology / Pharmacology

SUNY Downstate Health Sciences University

Umeå University
SUNY Downstate Health Sciences University

Research output: Contribution to journal › Article › peer-review

116 Scopus citations

Abstract

Premenstrual dysphoric disorder (PMDD) is characterized by depression, anxiety and other affective symptoms which recur in the luteal phase of the menstrual cycle. Evidence from animal models of depression and anxiety indicate the importance of neuroactive steroid hormones and the GABA_A receptor in the etiology and potential treatment of mood disorders. These data are reviewed in the light of human clinical studies and specific animal models of PMDD.

Original language	English
Pages (from-to)	23-41
Number of pages	19
Journal	Archives of Women's Mental Health
Volume	6
Issue number	1
DOIs	https://doi.org/10.1007/s00737-002-0147-1
State	Published - Feb 2003

Keywords

Allopregnanolone
Animal model
Anxiety
Benzodiazepine
Depression
GABA
GABAR subunit
Human
Mood
Neurosteroid
Premenstrual dysphoric disorder PMDD
Progesterone
Stress

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10.1007/s00737-002-0147-1

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abstract = "Premenstrual dysphoric disorder (PMDD) is characterized by depression, anxiety and other affective symptoms which recur in the luteal phase of the menstrual cycle. Evidence from animal models of depression and anxiety indicate the importance of neuroactive steroid hormones and the GABAA receptor in the etiology and potential treatment of mood disorders. These data are reviewed in the light of human clinical studies and specific animal models of PMDD.",

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AU - Smith, S.

AU - Gulinello, M.

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AB - Premenstrual dysphoric disorder (PMDD) is characterized by depression, anxiety and other affective symptoms which recur in the luteal phase of the menstrual cycle. Evidence from animal models of depression and anxiety indicate the importance of neuroactive steroid hormones and the GABAA receptor in the etiology and potential treatment of mood disorders. These data are reviewed in the light of human clinical studies and specific animal models of PMDD.

KW - Allopregnanolone

KW - Animal model

KW - Anxiety

KW - Benzodiazepine

KW - Depression

KW - GABA

KW - GABAR subunit

KW - Human

KW - Mood

KW - Neurosteroid

KW - Premenstrual dysphoric disorder PMDD

KW - Progesterone

KW - Stress

UR - https://www.scopus.com/pages/publications/0037298949

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ER -

GABA receptors, progesterone and premenstrual dysphoric disorder

Abstract

Keywords

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