Gap junctions in CO2-chemoreception and respiratory control

Irene C. Solomon; Jay B. Dean

doi:10.1016/S1569-9048(02)00090-3

Gap junctions in CO₂-chemoreception and respiratory control

Irene C. Solomon
, Jay B. Dean

Physiology and Biophysics

Stony Brook University

Wright State University

Research output: Contribution to journal › Review article › peer-review

24 Scopus citations

Abstract

Recent evidence indicates that gap junctions play a more prominent role in normal functioning of the mammalian central nervous system (CNS) than was once believed. Accumulating evidence from both neonatal and adult rodents indicates that gap junctions participate in multiple aspects of respiratory control, including central CO₂ chemoreception, respiratory rhythmogenesis, and respiratory motoneuron output. This review provides an overview of gap junction neurobiology in the mammalian CNS and presents the anatomical and electrophysiological evidence for gap junctions in CO₂ chemoreception and respiratory control.

Original language	English
Pages (from-to)	155-173
Number of pages	19
Journal	Respiratory Physiology and Neurobiology
Volume	131
Issue number	3
DOIs	https://doi.org/10.1016/S1569-9048(02)00090-3
State	Published - 2002

Keywords

CO, central chemosensitivity
Chemosensitivity, central, gap junctions
Connexin, gap junctions, respiratory control
Control of breathing, central chemosensitivity, respiratory rhythm generation
Gap junctions, central

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10.1016/S1569-9048(02)00090-3

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title = "Gap junctions in CO2-chemoreception and respiratory control",

abstract = "Recent evidence indicates that gap junctions play a more prominent role in normal functioning of the mammalian central nervous system (CNS) than was once believed. Accumulating evidence from both neonatal and adult rodents indicates that gap junctions participate in multiple aspects of respiratory control, including central CO2 chemoreception, respiratory rhythmogenesis, and respiratory motoneuron output. This review provides an overview of gap junction neurobiology in the mammalian CNS and presents the anatomical and electrophysiological evidence for gap junctions in CO2 chemoreception and respiratory control.",

keywords = "CO, central chemosensitivity, Chemosensitivity, central, gap junctions, Connexin, gap junctions, respiratory control, Control of breathing, central chemosensitivity, respiratory rhythm generation, Gap junctions, central",

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AU - Solomon, Irene C.

AU - Dean, Jay B.

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AB - Recent evidence indicates that gap junctions play a more prominent role in normal functioning of the mammalian central nervous system (CNS) than was once believed. Accumulating evidence from both neonatal and adult rodents indicates that gap junctions participate in multiple aspects of respiratory control, including central CO2 chemoreception, respiratory rhythmogenesis, and respiratory motoneuron output. This review provides an overview of gap junction neurobiology in the mammalian CNS and presents the anatomical and electrophysiological evidence for gap junctions in CO2 chemoreception and respiratory control.

KW - CO, central chemosensitivity

KW - Chemosensitivity, central, gap junctions

KW - Connexin, gap junctions, respiratory control

KW - Control of breathing, central chemosensitivity, respiratory rhythm generation

KW - Gap junctions, central

UR - https://www.scopus.com/pages/publications/0036308811

U2 - 10.1016/S1569-9048(02)00090-3

DO - 10.1016/S1569-9048(02)00090-3

M3 - Review article

C2 - 12126918

SN - 1569-9048

VL - 131

SP - 155

EP - 173

JO - Respiratory Physiology and Neurobiology

JF - Respiratory Physiology and Neurobiology

IS - 3

ER -

Gap junctions in CO₂-chemoreception and respiratory control

Abstract

Keywords

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