Genetic diversity of the gene cluster encoding Longus, a type IV pilus of enterotoxigenic Escherichia coli

Oscar G. Gomez-Duarte; Sujay Chattopadhyay; Scott J. Weissman; Jorge A. Giron; James B. Kaper; Evgeni V. Sokurenko

doi:10.1128/JB.00722-07

Genetic diversity of the gene cluster encoding Longus, a type IV pilus of enterotoxigenic Escherichia coli

Oscar G. Gomez-Duarte
, Sujay Chattopadhyay
, Scott J. Weissman
, Jorge A. Giron
, James B. Kaper
, Evgeni V. Sokurenko

Department of Epidemiology and Environmental Health

University at Buffalo

University of Washington
University of Arizona
University of Maryland, Baltimore

Research output: Contribution to journal › Article › peer-review

28 Scopus citations

Abstract

Enterotoxigenic Escherichia coli (ETEC) strains produce a type IV pilus named Longus. We identified a 16-gene cluster involved in the biosynthesis of Longus that has 57 to 95% identity at the protein level to CFA/III, another type IV pilus of ETEC. Alleles of the Longus structural subunit gene lngA demonstrate a diversity of 12 to 19% at the protein level with strong positive selection for point replacements and horizontal transfer.

Original language	English
Pages (from-to)	9145-9149
Number of pages	5
Journal	Journal of Bacteriology
Volume	189
Issue number	24
DOIs	https://doi.org/10.1128/JB.00722-07
State	Published - Dec 2007

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title = "Genetic diversity of the gene cluster encoding Longus, a type IV pilus of enterotoxigenic Escherichia coli",

abstract = "Enterotoxigenic Escherichia coli (ETEC) strains produce a type IV pilus named Longus. We identified a 16-gene cluster involved in the biosynthesis of Longus that has 57 to 95\% identity at the protein level to CFA/III, another type IV pilus of ETEC. Alleles of the Longus structural subunit gene lngA demonstrate a diversity of 12 to 19\% at the protein level with strong positive selection for point replacements and horizontal transfer.",

author = "Gomez-Duarte, \{Oscar G.\} and Sujay Chattopadhyay and Weissman, \{Scott J.\} and Giron, \{Jorge A.\} and Kaper, \{James B.\} and Sokurenko, \{Evgeni V.\}",

year = "2007",

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AU - Gomez-Duarte, Oscar G.

AU - Chattopadhyay, Sujay

AU - Weissman, Scott J.

AU - Giron, Jorge A.

AU - Kaper, James B.

AU - Sokurenko, Evgeni V.

PY - 2007/12

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N2 - Enterotoxigenic Escherichia coli (ETEC) strains produce a type IV pilus named Longus. We identified a 16-gene cluster involved in the biosynthesis of Longus that has 57 to 95% identity at the protein level to CFA/III, another type IV pilus of ETEC. Alleles of the Longus structural subunit gene lngA demonstrate a diversity of 12 to 19% at the protein level with strong positive selection for point replacements and horizontal transfer.

AB - Enterotoxigenic Escherichia coli (ETEC) strains produce a type IV pilus named Longus. We identified a 16-gene cluster involved in the biosynthesis of Longus that has 57 to 95% identity at the protein level to CFA/III, another type IV pilus of ETEC. Alleles of the Longus structural subunit gene lngA demonstrate a diversity of 12 to 19% at the protein level with strong positive selection for point replacements and horizontal transfer.

UR - https://www.scopus.com/pages/publications/37449021853

U2 - 10.1128/JB.00722-07

DO - 10.1128/JB.00722-07

M3 - Article

C2 - 17951389

SN - 0021-9193

VL - 189

SP - 9145

EP - 9149

JO - Journal of Bacteriology

JF - Journal of Bacteriology

IS - 24

ER -

Genetic diversity of the gene cluster encoding Longus, a type IV pilus of enterotoxigenic Escherichia coli

Abstract

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