Group i mGluR-dependent epileptogenesis

Group I metabotopic glutamate receptors (mGluRs) can initiate protein synthesis-dependent intracellular signaling processes that can result in enhanced expression of ictal-length discharges. Studies reveal that the fragile X syndrome phenotype is mediated by excessive mGluR-driven protein synthesis. Defective endogenous regulation of mGluR effects may thus enhance patient susceptibility to epileptogenesis. For an expanded treatment of this topic see Jasper's Basic Mechanisms of the Epilepsies, Fourth Edition (Noebels JL, Avoli M, Rogawski MA, Olsen RW, Delgado-Escueta AV, eds) published by Oxford University Press (available on the National Library of Medicine Bookshelf [NCBI] at).