High-density, multiplexed patterning of cells at single-cell resolution for tissue engineering and other applications

Udi Vermesh; Ophir Vermesh; Jun Wang; Gabriel A. Kwong; Chao Ma; Kiwook Hwang; James R. Heath

doi:10.1002/anie.201102249

High-density, multiplexed patterning of cells at single-cell resolution for tissue engineering and other applications

Udi Vermesh
, Ophir Vermesh
, Jun Wang
, Gabriel A. Kwong
, Chao Ma
, Kiwook Hwang
, James R. Heath

Biomedical Engineering

Stony Brook University

California Institute of Technology
Massachusetts Institute of Technology

Research output: Contribution to journal › Article › peer-review

57 Scopus citations

Abstract

Surface chemistry meets tissue engineering: A novel surface-patterning approach for creating arrays of DNA squares is combined with a unique method for DNA-encoding of cells to construct dense arrays of distinct single cells. The cell patterns can be transferred from the substrate surface into thin hydrogel films, and these layers can be stacked to form 3D tissue constructs.

Original language	English
Pages (from-to)	7378-7380
Number of pages	3
Journal	Angewandte Chemie - International Edition
Volume	50
Issue number	32
DOIs	https://doi.org/10.1002/anie.201102249
State	Published - Aug 1 2011

Keywords

cell assembly
flow-patterning
microarrays
microfluidics
tissue engineering

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10.1002/anie.201102249

Cite this

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title = "High-density, multiplexed patterning of cells at single-cell resolution for tissue engineering and other applications",

abstract = "Surface chemistry meets tissue engineering: A novel surface-patterning approach for creating arrays of DNA squares is combined with a unique method for DNA-encoding of cells to construct dense arrays of distinct single cells. The cell patterns can be transferred from the substrate surface into thin hydrogel films, and these layers can be stacked to form 3D tissue constructs.",

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author = "Udi Vermesh and Ophir Vermesh and Jun Wang and Kwong, \{Gabriel A.\} and Chao Ma and Kiwook Hwang and Heath, \{James R.\}",

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AU - Vermesh, Udi

AU - Vermesh, Ophir

AU - Wang, Jun

AU - Kwong, Gabriel A.

AU - Ma, Chao

AU - Hwang, Kiwook

AU - Heath, James R.

PY - 2011/8/1

Y1 - 2011/8/1

N2 - Surface chemistry meets tissue engineering: A novel surface-patterning approach for creating arrays of DNA squares is combined with a unique method for DNA-encoding of cells to construct dense arrays of distinct single cells. The cell patterns can be transferred from the substrate surface into thin hydrogel films, and these layers can be stacked to form 3D tissue constructs.

AB - Surface chemistry meets tissue engineering: A novel surface-patterning approach for creating arrays of DNA squares is combined with a unique method for DNA-encoding of cells to construct dense arrays of distinct single cells. The cell patterns can be transferred from the substrate surface into thin hydrogel films, and these layers can be stacked to form 3D tissue constructs.

KW - cell assembly

KW - flow-patterning

KW - microarrays

KW - microfluidics

KW - tissue engineering

UR - https://www.scopus.com/pages/publications/79960903160

U2 - 10.1002/anie.201102249

DO - 10.1002/anie.201102249

M3 - Article

C2 - 21717543

SN - 1433-7851

VL - 50

SP - 7378

EP - 7380

JO - Angewandte Chemie - International Edition

JF - Angewandte Chemie - International Edition

IS - 32

ER -

High-density, multiplexed patterning of cells at single-cell resolution for tissue engineering and other applications

Abstract

Keywords

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