TY - GEN
T1 - Highly sensitive single photon detection system for multi-lane DNA sequencer
AU - Gavrilov, Dmitri
AU - Gorbovitski, Boris
AU - Gudkov, Georgiy
AU - Stepukhovich, Andrey
AU - Tcherevishnik, Marina
AU - Tyshko, Georgiy
AU - Tsupryk, Andriy
AU - Gorfinkel, Vera
PY - 2006
Y1 - 2006
N2 - A multichannel fluorescence detection system for multi-lane DNA sequencer based on single photon counting is presented. The problem of elimination of the lane cross-talk caused by both optical and electronic cross-talk between the detection lanes is discussed. A novel method for elimination of the channel cross-talk is proposed. The calibration procedure for a DNA sequencer with lane cross-talk cancellation is described. Improvement in sensitivity of a DNA sequencer setup by introducing wide collection angle optical system is discussed.
AB - A multichannel fluorescence detection system for multi-lane DNA sequencer based on single photon counting is presented. The problem of elimination of the lane cross-talk caused by both optical and electronic cross-talk between the detection lanes is discussed. A novel method for elimination of the channel cross-talk is proposed. The calibration procedure for a DNA sequencer with lane cross-talk cancellation is described. Improvement in sensitivity of a DNA sequencer setup by introducing wide collection angle optical system is discussed.
KW - Cross-talk cancellation
KW - DNA sequencing
KW - Multichannel fluorescence detector
KW - Single photon counting
UR - https://www.scopus.com/pages/publications/33846263420
U2 - 10.1117/12.685404
DO - 10.1117/12.685404
M3 - Conference contribution
SN - 0819464708
SN - 9780819464705
T3 - Proceedings of SPIE - The International Society for Optical Engineering
BT - Advanced Photon Counting Techniques
T2 - Advanced Photon Counting Techniques
Y2 - 1 October 2006 through 3 October 2006
ER -