Homecoming of the estranged GluD channels

Jamie A. Abbott; Gabriela K. Popescu

doi:10.1016/j.tins.2022.04.001

Homecoming of the estranged GluD channels

Jamie A. Abbott
, Gabriela K. Popescu

Biochemistry

University at Buffalo

SUNY Buffalo

Research output: Contribution to journal › Short survey › peer-review

4 Scopus citations

Abstract

A recent paper by Carrillo and colleagues demonstrates that GluD proteins form bona fide ligand-gated ion channels when their intrinsic flexibility is constrained by interactions with protein partners. Therefore, Delta receptors resemble all other members of the ionotropic glutamate receptor family not only by sequence and structural homology, but also by functional dynamics.

Original language	English
Pages (from-to)	499-501
Number of pages	3
Journal	Trends in Neurosciences
Volume	45
Issue number	7
DOIs	https://doi.org/10.1016/j.tins.2022.04.001
State	Published - Jul 2022

Keywords

FRET
delta receptors
ionotropic glutamate receptors
ligand-gated ion channels
synaptic transmission

Access to Document

10.1016/j.tins.2022.04.001

Cite this

@article{8aa98ce63e1746d9a6bd2e9f59d52baf,

title = "Homecoming of the estranged GluD channels",

abstract = "A recent paper by Carrillo and colleagues demonstrates that GluD proteins form bona fide ligand-gated ion channels when their intrinsic flexibility is constrained by interactions with protein partners. Therefore, Delta receptors resemble all other members of the ionotropic glutamate receptor family not only by sequence and structural homology, but also by functional dynamics.",

keywords = "FRET, delta receptors, ionotropic glutamate receptors, ligand-gated ion channels, synaptic transmission",

author = "Abbott, \{Jamie A.\} and Popescu, \{Gabriela K.\}",

note = "Publisher Copyright: {\textcopyright} 2022 Elsevier Ltd",

year = "2022",

month = jul,

doi = "10.1016/j.tins.2022.04.001",

language = "English",

volume = "45",

pages = "499--501",

journal = "Trends in Neurosciences",

issn = "0166-2236",

publisher = "Elsevier Ltd.",

number = "7",

}

TY - JOUR

T1 - Homecoming of the estranged GluD channels

AU - Abbott, Jamie A.

AU - Popescu, Gabriela K.

PY - 2022/7

Y1 - 2022/7

N2 - A recent paper by Carrillo and colleagues demonstrates that GluD proteins form bona fide ligand-gated ion channels when their intrinsic flexibility is constrained by interactions with protein partners. Therefore, Delta receptors resemble all other members of the ionotropic glutamate receptor family not only by sequence and structural homology, but also by functional dynamics.

AB - A recent paper by Carrillo and colleagues demonstrates that GluD proteins form bona fide ligand-gated ion channels when their intrinsic flexibility is constrained by interactions with protein partners. Therefore, Delta receptors resemble all other members of the ionotropic glutamate receptor family not only by sequence and structural homology, but also by functional dynamics.

KW - FRET

KW - delta receptors

KW - ionotropic glutamate receptors

KW - ligand-gated ion channels

KW - synaptic transmission

UR - https://www.scopus.com/pages/publications/85129877108

U2 - 10.1016/j.tins.2022.04.001

DO - 10.1016/j.tins.2022.04.001

M3 - Short survey

C2 - 35490056

SN - 0166-2236

VL - 45

SP - 499

EP - 501

JO - Trends in Neurosciences

JF - Trends in Neurosciences

IS - 7

ER -

Homecoming of the estranged GluD channels

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this