How bacterial protein toxins enter cells: the role of partial unfolding in membrane translocation

Erwin London

doi:10.1111/j.1365-2958.1992.tb02195.x

How bacterial protein toxins enter cells: the role of partial unfolding in membrane translocation

Erwin London

Biochemistry and Cell Biology

Stony Brook University

Research output: Contribution to journal › Article › peer-review

59 Scopus citations

Abstract

Bacterial protein toxins translocate across membranes by processes that are still mysterious. Studies on diphtheria toxin have shown that partial unfolding processes play a major role in toxin membrane insertion and translocation. Similar unfolding behaviour is seen with other bacterial toxins. The lessons gained from this behaviour allow us to propose novel mechanisms for toxin translocation.

Original language	English
Pages (from-to)	3277-3282
Number of pages	6
Journal	Molecular Microbiology
Volume	6
Issue number	22
DOIs	https://doi.org/10.1111/j.1365-2958.1992.tb02195.x
State	Published - Nov 1992

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title = "How bacterial protein toxins enter cells: the role of partial unfolding in membrane translocation",

abstract = "Bacterial protein toxins translocate across membranes by processes that are still mysterious. Studies on diphtheria toxin have shown that partial unfolding processes play a major role in toxin membrane insertion and translocation. Similar unfolding behaviour is seen with other bacterial toxins. The lessons gained from this behaviour allow us to propose novel mechanisms for toxin translocation.",

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AB - Bacterial protein toxins translocate across membranes by processes that are still mysterious. Studies on diphtheria toxin have shown that partial unfolding processes play a major role in toxin membrane insertion and translocation. Similar unfolding behaviour is seen with other bacterial toxins. The lessons gained from this behaviour allow us to propose novel mechanisms for toxin translocation.

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JO - Molecular Microbiology

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How bacterial protein toxins enter cells: the role of partial unfolding in membrane translocation

Abstract

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