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How does PKM¶ maintain long-term memory?

Research output: Contribution to journalArticlepeer-review

337 Scopus citations

Abstract

Most of the molecular mechanisms contributing to long-term memory have been found to consolidate information within a brief time window after learning, but not to maintain information during memory storage. However, with the discovery that synaptic long-term potentiation is maintained by the persistently active protein kinase, protein kinase M ¶ (PKM ¶), a possible mechanism of memory storage has been identified. Recent research shows how PKM ¶ might perpetuate information both at synapses and during long-term memory.

Original languageEnglish
Pages (from-to)9-15
Number of pages7
JournalNature Reviews Neuroscience
Volume12
Issue number1
DOIs
StatePublished - Jan 2011

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