Human PK Prediction and Modeling

The emergence of in silico tools, such as physiologically based pharmacokinetic modeling, to predict human pharmacokinetics for new compounds now provides the ability to anticipate the advantages and liabilities associated with compounds in discovery. Physiologically based pharmacokinetic modeling is being used in diverse applications including simulation of preclinical, Phase 1 healthy volunteer, and special population pharmacokinetics; formulation optimization and food effects; and predicting the magnitude of drug-drug interactions. These applications are having a significant impact throughout drug discovery and development to increase efficiency, reduce the need for animal studies, and increase pharmacokinetic understanding in order to optimize development programs.