Human salivary eicosanoids: Circadian variation

Basil Rigas; Lawrence Levine

doi:10.1016/0006-291X(83)90989-0

Human salivary eicosanoids: Circadian variation

Basil Rigas
, Lawrence Levine

Family , Population and Preventative Medicine

Stony Brook University

Brandeis University

Research output: Contribution to journal › Article › peer-review

34 Scopus citations

Abstract

A circadian rhythm in the concentrations of prostaglandins (PG) E₂, PGF₂, PGI₂ (measured as 6-keto-PGF_1α), immunoreactive hydroxyeicosatetraenoic acids and immunoreactive 6-sulfidopeptide containing leukotrienes in human mixed saliva was observed. The rhythm reflected changes in the absolute amounts of these compounds in saliva. Under usual sleep-wake cycles a single peak occurred during sleep with maximal levels at 5:00 AM; the amplitude of the peak varied for each product. The rhythm was sleep-dependent and a shift occurred when the sleep-wake cycles were displaced. Basal levels of these eicosanoids were maintained even without sleep.

Original language	English
Pages (from-to)	201-205
Number of pages	5
Journal	Biochemical and Biophysical Research Communications
Volume	115
Issue number	1
DOIs	https://doi.org/10.1016/0006-291X(83)90989-0
State	Published - Aug 30 1983

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10.1016/0006-291X(83)90989-0

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title = "Human salivary eicosanoids: Circadian variation",

abstract = "A circadian rhythm in the concentrations of prostaglandins (PG) E2, PGF2, PGI2 (measured as 6-keto-PGF1α), immunoreactive hydroxyeicosatetraenoic acids and immunoreactive 6-sulfidopeptide containing leukotrienes in human mixed saliva was observed. The rhythm reflected changes in the absolute amounts of these compounds in saliva. Under usual sleep-wake cycles a single peak occurred during sleep with maximal levels at 5:00 AM; the amplitude of the peak varied for each product. The rhythm was sleep-dependent and a shift occurred when the sleep-wake cycles were displaced. Basal levels of these eicosanoids were maintained even without sleep.",

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TY - JOUR

T1 - Human salivary eicosanoids

T2 - Circadian variation

AU - Rigas, Basil

AU - Levine, Lawrence

PY - 1983/8/30

Y1 - 1983/8/30

N2 - A circadian rhythm in the concentrations of prostaglandins (PG) E2, PGF2, PGI2 (measured as 6-keto-PGF1α), immunoreactive hydroxyeicosatetraenoic acids and immunoreactive 6-sulfidopeptide containing leukotrienes in human mixed saliva was observed. The rhythm reflected changes in the absolute amounts of these compounds in saliva. Under usual sleep-wake cycles a single peak occurred during sleep with maximal levels at 5:00 AM; the amplitude of the peak varied for each product. The rhythm was sleep-dependent and a shift occurred when the sleep-wake cycles were displaced. Basal levels of these eicosanoids were maintained even without sleep.

AB - A circadian rhythm in the concentrations of prostaglandins (PG) E2, PGF2, PGI2 (measured as 6-keto-PGF1α), immunoreactive hydroxyeicosatetraenoic acids and immunoreactive 6-sulfidopeptide containing leukotrienes in human mixed saliva was observed. The rhythm reflected changes in the absolute amounts of these compounds in saliva. Under usual sleep-wake cycles a single peak occurred during sleep with maximal levels at 5:00 AM; the amplitude of the peak varied for each product. The rhythm was sleep-dependent and a shift occurred when the sleep-wake cycles were displaced. Basal levels of these eicosanoids were maintained even without sleep.

UR - https://www.scopus.com/pages/publications/0020551237

U2 - 10.1016/0006-291X(83)90989-0

DO - 10.1016/0006-291X(83)90989-0

M3 - Article

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SN - 0006-291X

VL - 115

SP - 201

EP - 205

JO - Biochemical and Biophysical Research Communications

JF - Biochemical and Biophysical Research Communications

IS - 1

ER -

Human salivary eicosanoids: Circadian variation

Abstract

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