Abstract
We compared the effects of infused norepinephrine (NE) to another alpha-adrenergic agonist, phenylephrine, in order to understand better the influence of circulating NE on plasma renin activity (PRA) in man. In matched groups of normotensive men, NE (80 ng/min/kg) or phenylephrine (800 ng/min/kg) raised blood pressure by 15 to 20 mm Hg and caused reflex decreases in heart rate of 8 to 10 beats per minute. Infused phenylephrine suppressed PRA by about 15%, whereas NE increased PRA by about 4 0% (P `.02). This differential effect of alpha-agonists on P RA defines an important humoral effect of NE, which should b e considered to be a "cardiovascular hormone/' Am J Hypertens 1989;2:788-791.
| Original language | English |
|---|---|
| Pages (from-to) | 788-791 |
| Number of pages | 4 |
| Journal | American Journal of Hypertension |
| Volume | 2 |
| Issue number | 10 |
| DOIs | |
| State | Published - Oct 1989 |
Keywords
- Alphaadrenergic agonists
- Norepinephrine
- Plasma renin
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