Immobilization of DNA for scanning probe microscopy

D. P. Allison; L. A. Bottomley; T. Thundat; G. M. Brown; R. P. Woychik; J. J. Schrick; K. Bruce Jacobson; R. J. Warmack

doi:10.1073/pnas.89.21.10129

Immobilization of DNA for scanning probe microscopy

D. P. Allison
, L. A. Bottomley
, T. Thundat
, G. M. Brown
, R. P. Woychik
, J. J. Schrick
, K. Bruce Jacobson
, R. J. Warmack

Department of Chemical and Biological Engineering

University at Buffalo

Research output: Contribution to journal › Article › peer-review

53 Scopus citations

Abstract

Reproducible scanning tunneling microscope and atomic force microscope images of entire molecules of uncoated plasmid DNA chemically bound to surfaces are presented. The chemically mediated immobilization of DNA to surfaces and subsequent scanning tunneling microscope imaging of DNA molecules demonstrate that the problem of molecular instability to forces exerted by the probe tip, inherent with scanning probe microscopes, can be prevented.

Original language	English
Pages (from-to)	10129-10133
Number of pages	5
Journal	Proceedings of the National Academy of Sciences of the United States of America
Volume	89
Issue number	21
DOIs	https://doi.org/10.1073/pnas.89.21.10129
State	Published - 1992

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10.1073/pnas.89.21.10129

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title = "Immobilization of DNA for scanning probe microscopy",

abstract = "Reproducible scanning tunneling microscope and atomic force microscope images of entire molecules of uncoated plasmid DNA chemically bound to surfaces are presented. The chemically mediated immobilization of DNA to surfaces and subsequent scanning tunneling microscope imaging of DNA molecules demonstrate that the problem of molecular instability to forces exerted by the probe tip, inherent with scanning probe microscopes, can be prevented.",

author = "Allison, \{D. P.\} and Bottomley, \{L. A.\} and T. Thundat and Brown, \{G. M.\} and Woychik, \{R. P.\} and Schrick, \{J. J.\} and \{Bruce Jacobson\}, K. and Warmack, \{R. J.\}",

year = "1992",

doi = "10.1073/pnas.89.21.10129",

language = "English",

volume = "89",

pages = "10129--10133",

journal = "Proceedings of the National Academy of Sciences of the United States of America",

issn = "0027-8424",

publisher = "National Academy of Sciences",

number = "21",

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TY - JOUR

T1 - Immobilization of DNA for scanning probe microscopy

AU - Allison, D. P.

AU - Bottomley, L. A.

AU - Thundat, T.

AU - Brown, G. M.

AU - Woychik, R. P.

AU - Schrick, J. J.

AU - Bruce Jacobson, K.

AU - Warmack, R. J.

PY - 1992

Y1 - 1992

N2 - Reproducible scanning tunneling microscope and atomic force microscope images of entire molecules of uncoated plasmid DNA chemically bound to surfaces are presented. The chemically mediated immobilization of DNA to surfaces and subsequent scanning tunneling microscope imaging of DNA molecules demonstrate that the problem of molecular instability to forces exerted by the probe tip, inherent with scanning probe microscopes, can be prevented.

AB - Reproducible scanning tunneling microscope and atomic force microscope images of entire molecules of uncoated plasmid DNA chemically bound to surfaces are presented. The chemically mediated immobilization of DNA to surfaces and subsequent scanning tunneling microscope imaging of DNA molecules demonstrate that the problem of molecular instability to forces exerted by the probe tip, inherent with scanning probe microscopes, can be prevented.

UR - https://www.scopus.com/pages/publications/0026439208

U2 - 10.1073/pnas.89.21.10129

DO - 10.1073/pnas.89.21.10129

M3 - Article

C2 - 1438201

SN - 0027-8424

VL - 89

SP - 10129

EP - 10133

JO - Proceedings of the National Academy of Sciences of the United States of America

JF - Proceedings of the National Academy of Sciences of the United States of America

IS - 21

ER -

Immobilization of DNA for scanning probe microscopy

Abstract

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