Improvement in time to multiple sclerosis diagnosis: 25-year retrospective analysis from New York State MS Consortium (NYSMSC)

Dejan Jakimovski; Katelyn S. Kavak; Karen Zakalik; Timothy Coetzee; Malcolm Gottesman; Patricia K. Coyle; Robert Zivadinov; Bianca Weinstock-Guttman

doi:10.1177/13524585221140271

Improvement in time to multiple sclerosis diagnosis: 25-year retrospective analysis from New York State MS Consortium (NYSMSC)

Dejan Jakimovski
, Katelyn S. Kavak
, Karen Zakalik
, Timothy Coetzee
, Malcolm Gottesman
, Patricia K. Coyle
, Robert Zivadinov
, Bianca Weinstock-Guttman

University at Buffalo, Stony Brook University

SUNY Buffalo
National Multiple Sclerosis Society
NYU Langone Ambulatory Care
Stony Brook University

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

Judicious multiple sclerosis (MS) diagnosis and early start of disease modifying therapy significantly improves long-term disability outcomes in persons with MS (pwMS). Retrospective analysis based on 25-year New York State MS Consortium (NYSMSC) data determined the effect of changes in the respective diagnostic criteria in shortening the time between symptom onset to MS diagnosis. Based on 9378 current and historical MS cases, there was a significant decrease in time to diagnosis in pwMS from 1982–2001 to >2017 periods (average 4.2 vs. 1.1 years, p < 0.001). Additional improvements and better implementation of the MS diagnostic criteria can further decrease the diagnosis lag.

Original language	English
Pages (from-to)	753-756
Number of pages	4
Journal	Multiple Sclerosis Journal
Volume	29
Issue number	6
DOIs	https://doi.org/10.1177/13524585221140271
State	Published - May 2023

Keywords

Multiple sclerosis
diagnosis
diagnostic criteria
diagnostic lag

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10.1177/13524585221140271

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title = "Improvement in time to multiple sclerosis diagnosis: 25-year retrospective analysis from New York State MS Consortium (NYSMSC)",

abstract = "Judicious multiple sclerosis (MS) diagnosis and early start of disease modifying therapy significantly improves long-term disability outcomes in persons with MS (pwMS). Retrospective analysis based on 25-year New York State MS Consortium (NYSMSC) data determined the effect of changes in the respective diagnostic criteria in shortening the time between symptom onset to MS diagnosis. Based on 9378 current and historical MS cases, there was a significant decrease in time to diagnosis in pwMS from 1982–2001 to >2017 periods (average 4.2 vs. 1.1 years, p < 0.001). Additional improvements and better implementation of the MS diagnostic criteria can further decrease the diagnosis lag.",

keywords = "Multiple sclerosis, diagnosis, diagnostic criteria, diagnostic lag",

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T2 - 25-year retrospective analysis from New York State MS Consortium (NYSMSC)

AU - Jakimovski, Dejan

AU - Kavak, Katelyn S.

AU - Zakalik, Karen

AU - Coetzee, Timothy

AU - Gottesman, Malcolm

AU - Coyle, Patricia K.

AU - Zivadinov, Robert

AU - Weinstock-Guttman, Bianca

N1 - Publisher Copyright: © The Author(s), 2022.

PY - 2023/5

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N2 - Judicious multiple sclerosis (MS) diagnosis and early start of disease modifying therapy significantly improves long-term disability outcomes in persons with MS (pwMS). Retrospective analysis based on 25-year New York State MS Consortium (NYSMSC) data determined the effect of changes in the respective diagnostic criteria in shortening the time between symptom onset to MS diagnosis. Based on 9378 current and historical MS cases, there was a significant decrease in time to diagnosis in pwMS from 1982–2001 to >2017 periods (average 4.2 vs. 1.1 years, p < 0.001). Additional improvements and better implementation of the MS diagnostic criteria can further decrease the diagnosis lag.

AB - Judicious multiple sclerosis (MS) diagnosis and early start of disease modifying therapy significantly improves long-term disability outcomes in persons with MS (pwMS). Retrospective analysis based on 25-year New York State MS Consortium (NYSMSC) data determined the effect of changes in the respective diagnostic criteria in shortening the time between symptom onset to MS diagnosis. Based on 9378 current and historical MS cases, there was a significant decrease in time to diagnosis in pwMS from 1982–2001 to >2017 periods (average 4.2 vs. 1.1 years, p < 0.001). Additional improvements and better implementation of the MS diagnostic criteria can further decrease the diagnosis lag.

KW - Multiple sclerosis

KW - diagnosis

KW - diagnostic criteria

KW - diagnostic lag

UR - https://www.scopus.com/pages/publications/85145997469

U2 - 10.1177/13524585221140271

DO - 10.1177/13524585221140271

M3 - Article

C2 - 36545928

SN - 1352-4585

VL - 29

SP - 753

EP - 756

JO - Multiple Sclerosis Journal

JF - Multiple Sclerosis Journal

IS - 6

ER -

Improvement in time to multiple sclerosis diagnosis: 25-year retrospective analysis from New York State MS Consortium (NYSMSC)

Abstract

Keywords

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