In search of engram cells

Dheeraj S. Roy; Susumu Tonegawa

doi:10.1016/B978-0-12-809324-5.21124-3

In search of engram cells

Dheeraj S. Roy
, Susumu Tonegawa

Physiology and Biophysics

University at Buffalo

Massachusetts Institute of Technology

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

1 Scopus citations

Abstract

One of the most fascinating aspects of an animal’s brain is its ability to acquire new information from experience and retain this information over time as memory. The search for physical correlates of memory, the memory engram, has been a long-standing question in modern neurobiology. Recent advances in transgenics and optogenetic tools have enabled the identification, visualization, and manipulation of natural, sensory-evoked, engram ensembles unique to individual brain regions, and specific learning events. We suggest that these recent studies are paving the way not only to understand memory mechanisms in unprecedented detail but also to engineer the memory-mediated state of mind and behaviors.

Original language	English
Title of host publication	The Curated Reference Collection in Neuroscience and Biobehavioral Psychology
Publisher	Elsevier Science Ltd.
Pages	637-658
Number of pages	22
ISBN (Electronic)	9780128093245
DOIs	https://doi.org/10.1016/B978-0-12-809324-5.21124-3
State	Published - Jan 1 2016

Keywords

Connectivity
Consolidation
Encoding
Engram cells
Episodic memory
Excitability
Extinction
Learning
Long-term potentiation
Memory trace
Neuronal ensembles
Plasticity
Retrieval
Retrograde amnesia
Storage

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10.1016/B978-0-12-809324-5.21124-3

Cite this

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KW - Consolidation

KW - Encoding

KW - Engram cells

KW - Episodic memory

KW - Excitability

KW - Extinction

KW - Learning

KW - Long-term potentiation

KW - Memory trace

KW - Neuronal ensembles

KW - Plasticity

KW - Retrieval

KW - Retrograde amnesia

KW - Storage

UR - https://www.scopus.com/pages/publications/85050243530

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DO - 10.1016/B978-0-12-809324-5.21124-3

M3 - Chapter

SP - 637

EP - 658

BT - The Curated Reference Collection in Neuroscience and Biobehavioral Psychology

PB - Elsevier Science Ltd.

ER -

In search of engram cells

Abstract

Keywords

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