@inproceedings{f619bd109e804eb18e6dfbd919a4314b,
title = "Indium phosphide: Cadmium free quantum dots for cancer imaging and therapy",
abstract = "Fluorescent semiconductor nanoparticles, or quantum dots (QDs), have attracted a lot of attention over the past decade due to their unique optical and chemical properties. Indium phosphide (InP) QDs have emerged as a replacement for the widely used cadmium based QDs but their cytotoxity has not been well examined. Several questions vis-ȧ- vis the InP QDs need to be addressed. Are they less toxic than CdSe/ZnS or CdTe? Are they as photoluminescent? Could they be used for imaging and photdynamic therapy (PDT)? Spin-trap electron paramagnetic resonance (EPR) spectroscopy and sulforhodamine B (SRB) viability assay indicates very low cytotoxicity in all cell lines tested, with toxicity proportional to ROS generation. Confocal microscopy showed none specific uptake of InP/ZnS concentrated in the perinuclear region. These data indicate that InP QDs are a viable alternative to cadmium-containing particles for biological applications.",
keywords = "Electron paramagnetic resonance, Imaging, InP/ZnS, Quantum dots, Reactive oxygen species, Toxicity",
author = "H. Chibli and L. Carlini and S. Park and N. Dimitrijevic and Nadeau, \{Jay L.\}",
year = "2011",
language = "English",
isbn = "9781439871386",
series = "Technical Proceedings of the 2011 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2011",
pages = "133--136",
booktitle = "Technical Proceedings of the 2011 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2011",
note = "Nanotechnology 2011: Electronics, Devices, Fabrication, MEMS, Fluidics and Computational - 2011 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2011 ; Conference date: 13-06-2011 Through 16-06-2011",
}