Abstract
Cystatin C, a potent inhibitor of cysteine proteases such as papain and cathepsin B, was examined for its effect on human coronaviruses OC43 and 229e. Both viruses were >99% inhibited by 0.1 mM inhibitor. Endpoint titrations showed that inhibiting activity paralleled that of leupeptin, a serine and cysteine protease inhibitor, and indicated that 1 to 2 μM inhibitor, slightly above physiologic levels, was effective.
| Original language | English |
|---|---|
| Pages (from-to) | 2444-2446 |
| Number of pages | 3 |
| Journal | Antimicrobial Agents and Chemotherapy |
| Volume | 35 |
| Issue number | 11 |
| DOIs | |
| State | Published - 1991 |
Fingerprint
Dive into the research topics of 'Inhibitory effects of recombinant human cystatin C on human coronaviruses'. Together they form a unique fingerprint.Cite this
- APA
- Author
- BIBTEX
- Harvard
- Standard
- RIS
- Vancouver