Integration of a photocleavable element into DNA nanoswitches

Arun Richard Chandrasekaran; Jibin Abraham Punnoose; Vibhav Valsangkar; Jia Sheng; Ken Halvorsen

doi:10.1039/c9cc03069g

Integration of a photocleavable element into DNA nanoswitches

Arun Richard Chandrasekaran
, Jibin Abraham Punnoose
, Vibhav Valsangkar
, Jia Sheng
, Ken Halvorsen

University at Albany

SUNY Albany

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

Reconfigurable DNA nanostructures can be designed to respond to external stimuli such as nucleic acids, pH, small molecules and enzymes. In this study, we incorporated photocleavable linkers in DNA strands that trigger a conformational change in binary DNA nanoswitches. We demonstrate control of the output using UV light, with potential applications in biosensing and molecular computation.

Original language	English
Pages (from-to)	6587-6590
Number of pages	4
Journal	Chemical Communications
Volume	55
Issue number	46
DOIs	https://doi.org/10.1039/c9cc03069g
State	Published - 2019

Access to Document

10.1039/c9cc03069g

Cite this

@article{2525f65c7e134262badb0e8a313229e6,

title = "Integration of a photocleavable element into DNA nanoswitches",

abstract = "Reconfigurable DNA nanostructures can be designed to respond to external stimuli such as nucleic acids, pH, small molecules and enzymes. In this study, we incorporated photocleavable linkers in DNA strands that trigger a conformational change in binary DNA nanoswitches. We demonstrate control of the output using UV light, with potential applications in biosensing and molecular computation.",

author = "Chandrasekaran, \{Arun Richard\} and \{Abraham Punnoose\}, Jibin and Vibhav Valsangkar and Jia Sheng and Ken Halvorsen",

note = "Publisher Copyright: {\textcopyright} The Royal Society of Chemistry 2019.",

year = "2019",

doi = "10.1039/c9cc03069g",

language = "English",

volume = "55",

pages = "6587--6590",

journal = "Chemical Communications",

issn = "1359-7345",

number = "46",

}

TY - JOUR

T1 - Integration of a photocleavable element into DNA nanoswitches

AU - Chandrasekaran, Arun Richard

AU - Abraham Punnoose, Jibin

AU - Valsangkar, Vibhav

AU - Sheng, Jia

AU - Halvorsen, Ken

N1 - Publisher Copyright: © The Royal Society of Chemistry 2019.

PY - 2019

Y1 - 2019

N2 - Reconfigurable DNA nanostructures can be designed to respond to external stimuli such as nucleic acids, pH, small molecules and enzymes. In this study, we incorporated photocleavable linkers in DNA strands that trigger a conformational change in binary DNA nanoswitches. We demonstrate control of the output using UV light, with potential applications in biosensing and molecular computation.

AB - Reconfigurable DNA nanostructures can be designed to respond to external stimuli such as nucleic acids, pH, small molecules and enzymes. In this study, we incorporated photocleavable linkers in DNA strands that trigger a conformational change in binary DNA nanoswitches. We demonstrate control of the output using UV light, with potential applications in biosensing and molecular computation.

UR - https://www.scopus.com/pages/publications/85066843319

U2 - 10.1039/c9cc03069g

DO - 10.1039/c9cc03069g

M3 - Article

C2 - 31116197

SN - 1359-7345

VL - 55

SP - 6587

EP - 6590

JO - Chemical Communications

JF - Chemical Communications

IS - 46

ER -

Integration of a photocleavable element into DNA nanoswitches

Abstract

Access to Document

Other files and links

Fingerprint

Cite this