Investigation of human serum albumin (HSA) binding specificity of certain photosensitizers related to pyropheophorbide-a and bacteriopurpurinimide by circular dichroism spectroscopy and its correlation with in vivo photosensitizing efficacy

Yihui Chen; Razvan Miclea; Thamarapu Srikrishnan; Sathyamangalam Balasubramanian; Thomas J. Dougherty; Ravindra K. Pandey

doi:10.1016/j.bmcl.2005.05.019

Investigation of human serum albumin (HSA) binding specificity of certain photosensitizers related to pyropheophorbide-a and bacteriopurpurinimide by circular dichroism spectroscopy and its correlation with in vivo photosensitizing efficacy

Yihui Chen
, Razvan Miclea
, Thamarapu Srikrishnan
, Sathyamangalam Balasubramanian
, Thomas J. Dougherty
, Ravindra K. Pandey

Institute for Lasers Photonics and Biophotonics

University at Buffalo

Roswell Park Cancer Institute
SUNY Buffalo

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

A series of pyropheophorbide-a and bacteriopurpurinimides were investigated to understand the correlation between HSA (site II) binding affinity and in vivo photosensitizing activity. In our study, photosensitizers that bound to site II of HSA produced a significant difference in the circular dichroism spectra of the corresponding complexes, especially at Soret band region of the photosensitizers. Our results suggest that CD spectroscopy of the photosensitizer-HSA complexes could be a valuable tool in screening new photosensitizers before evaluating them for in vivo efficacy.

Original language	English
Pages (from-to)	3189-3192
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	15
Issue number	13
DOIs	https://doi.org/10.1016/j.bmcl.2005.05.019
State	Published - Jul 1 2005

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Chen, Y., Miclea, R., Srikrishnan, T., Balasubramanian, S., Dougherty, T. J., & Pandey, R. K. (2005). Investigation of human serum albumin (HSA) binding specificity of certain photosensitizers related to pyropheophorbide-a and bacteriopurpurinimide by circular dichroism spectroscopy and its correlation with in vivo photosensitizing efficacy. Bioorganic and Medicinal Chemistry Letters, 15(13), 3189-3192. https://doi.org/10.1016/j.bmcl.2005.05.019

Chen, Yihui ; Miclea, Razvan ; Srikrishnan, Thamarapu et al. / Investigation of human serum albumin (HSA) binding specificity of certain photosensitizers related to pyropheophorbide-a and bacteriopurpurinimide by circular dichroism spectroscopy and its correlation with in vivo photosensitizing efficacy. In: Bioorganic and Medicinal Chemistry Letters. 2005 ; Vol. 15, No. 13. pp. 3189-3192.

@article{ce9b1d96708542309ecafcc47b1e3dee,

title = "Investigation of human serum albumin (HSA) binding specificity of certain photosensitizers related to pyropheophorbide-a and bacteriopurpurinimide by circular dichroism spectroscopy and its correlation with in vivo photosensitizing efficacy",

abstract = "A series of pyropheophorbide-a and bacteriopurpurinimides were investigated to understand the correlation between HSA (site II) binding affinity and in vivo photosensitizing activity. In our study, photosensitizers that bound to site II of HSA produced a significant difference in the circular dichroism spectra of the corresponding complexes, especially at Soret band region of the photosensitizers. Our results suggest that CD spectroscopy of the photosensitizer-HSA complexes could be a valuable tool in screening new photosensitizers before evaluating them for in vivo efficacy.",

author = "Yihui Chen and Razvan Miclea and Thamarapu Srikrishnan and Sathyamangalam Balasubramanian and Dougherty, \{Thomas J.\} and Pandey, \{Ravindra K.\}",

year = "2005",

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doi = "10.1016/j.bmcl.2005.05.019",

language = "English",

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Chen, Y, Miclea, R, Srikrishnan, T, Balasubramanian, S, Dougherty, TJ & Pandey, RK 2005, 'Investigation of human serum albumin (HSA) binding specificity of certain photosensitizers related to pyropheophorbide-a and bacteriopurpurinimide by circular dichroism spectroscopy and its correlation with in vivo photosensitizing efficacy', Bioorganic and Medicinal Chemistry Letters, vol. 15, no. 13, pp. 3189-3192. https://doi.org/10.1016/j.bmcl.2005.05.019

Investigation of human serum albumin (HSA) binding specificity of certain photosensitizers related to pyropheophorbide-a and bacteriopurpurinimide by circular dichroism spectroscopy and its correlation with in vivo photosensitizing efficacy. / Chen, Yihui; Miclea, Razvan; Srikrishnan, Thamarapu et al.
In: Bioorganic and Medicinal Chemistry Letters, Vol. 15, No. 13, 01.07.2005, p. 3189-3192.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Investigation of human serum albumin (HSA) binding specificity of certain photosensitizers related to pyropheophorbide-a and bacteriopurpurinimide by circular dichroism spectroscopy and its correlation with in vivo photosensitizing efficacy

AU - Chen, Yihui

AU - Miclea, Razvan

AU - Srikrishnan, Thamarapu

AU - Balasubramanian, Sathyamangalam

AU - Dougherty, Thomas J.

AU - Pandey, Ravindra K.

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N2 - A series of pyropheophorbide-a and bacteriopurpurinimides were investigated to understand the correlation between HSA (site II) binding affinity and in vivo photosensitizing activity. In our study, photosensitizers that bound to site II of HSA produced a significant difference in the circular dichroism spectra of the corresponding complexes, especially at Soret band region of the photosensitizers. Our results suggest that CD spectroscopy of the photosensitizer-HSA complexes could be a valuable tool in screening new photosensitizers before evaluating them for in vivo efficacy.

AB - A series of pyropheophorbide-a and bacteriopurpurinimides were investigated to understand the correlation between HSA (site II) binding affinity and in vivo photosensitizing activity. In our study, photosensitizers that bound to site II of HSA produced a significant difference in the circular dichroism spectra of the corresponding complexes, especially at Soret band region of the photosensitizers. Our results suggest that CD spectroscopy of the photosensitizer-HSA complexes could be a valuable tool in screening new photosensitizers before evaluating them for in vivo efficacy.

UR - https://www.scopus.com/pages/publications/20444368427

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JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

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ER -

Chen Y, Miclea R, Srikrishnan T, Balasubramanian S, Dougherty TJ, Pandey RK. Investigation of human serum albumin (HSA) binding specificity of certain photosensitizers related to pyropheophorbide-a and bacteriopurpurinimide by circular dichroism spectroscopy and its correlation with in vivo photosensitizing efficacy. Bioorganic and Medicinal Chemistry Letters. 2005 Jul 1;15(13):3189-3192. doi: 10.1016/j.bmcl.2005.05.019

Investigation of human serum albumin (HSA) binding specificity of certain photosensitizers related to pyropheophorbide-a and bacteriopurpurinimide by circular dichroism spectroscopy and its correlation with in vivo photosensitizing efficacy

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