Ionic liquids with thioether motifs as synthetic cationic lipids for gene delivery

Jamie C. Gaitor; Lauren M. Paul; Melissa M. Reardon; Taha Hmissa; Samuel Minkowicz; Matthew Regner; Yinghong Sheng; Scott F. Michael; Sharon Isern; Arsalan Mirjafari

doi:10.1039/c7cc03235h

Ionic liquids with thioether motifs as synthetic cationic lipids for gene delivery

Jamie C. Gaitor
, Lauren M. Paul
, Melissa M. Reardon
, Taha Hmissa
, Samuel Minkowicz
, Matthew Regner
, Yinghong Sheng
, Scott F. Michael
, Sharon Isern
, Arsalan Mirjafari

Chemistry

SUNY Oswego

Florida Gulf Coast University

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

This study introduces a novel class of imidazolium- and ammonium-based ionic liquids possessing two C₁₂ and C₁₄ tails and thioether linkers designed for lipoplex-mediated DNA delivery. Imidazolium-based ionic liquids displayed efficient gene delivery properties with low toxicity. Thiol-yne click chemistry was employed for the facile and robust synthesis of these thioether-based cationic lipioids with enhanced lipophilicity and low fluidity.

Original language	English
Pages (from-to)	8328-8331
Number of pages	4
Journal	Chemical Communications
Volume	53
Issue number	59
DOIs	https://doi.org/10.1039/c7cc03235h
State	Published - 2017

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title = "Ionic liquids with thioether motifs as synthetic cationic lipids for gene delivery",

abstract = "This study introduces a novel class of imidazolium- and ammonium-based ionic liquids possessing two C12 and C14 tails and thioether linkers designed for lipoplex-mediated DNA delivery. Imidazolium-based ionic liquids displayed efficient gene delivery properties with low toxicity. Thiol-yne click chemistry was employed for the facile and robust synthesis of these thioether-based cationic lipioids with enhanced lipophilicity and low fluidity.",

author = "Gaitor, \{Jamie C.\} and Paul, \{Lauren M.\} and Reardon, \{Melissa M.\} and Taha Hmissa and Samuel Minkowicz and Matthew Regner and Yinghong Sheng and Michael, \{Scott F.\} and Sharon Isern and Arsalan Mirjafari",

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year = "2017",

doi = "10.1039/c7cc03235h",

language = "English",

volume = "53",

pages = "8328--8331",

journal = "Chemical Communications",

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T1 - Ionic liquids with thioether motifs as synthetic cationic lipids for gene delivery

AU - Gaitor, Jamie C.

AU - Paul, Lauren M.

AU - Reardon, Melissa M.

AU - Hmissa, Taha

AU - Minkowicz, Samuel

AU - Regner, Matthew

AU - Sheng, Yinghong

AU - Michael, Scott F.

AU - Isern, Sharon

AU - Mirjafari, Arsalan

PY - 2017

Y1 - 2017

N2 - This study introduces a novel class of imidazolium- and ammonium-based ionic liquids possessing two C12 and C14 tails and thioether linkers designed for lipoplex-mediated DNA delivery. Imidazolium-based ionic liquids displayed efficient gene delivery properties with low toxicity. Thiol-yne click chemistry was employed for the facile and robust synthesis of these thioether-based cationic lipioids with enhanced lipophilicity and low fluidity.

AB - This study introduces a novel class of imidazolium- and ammonium-based ionic liquids possessing two C12 and C14 tails and thioether linkers designed for lipoplex-mediated DNA delivery. Imidazolium-based ionic liquids displayed efficient gene delivery properties with low toxicity. Thiol-yne click chemistry was employed for the facile and robust synthesis of these thioether-based cationic lipioids with enhanced lipophilicity and low fluidity.

UR - https://www.scopus.com/pages/publications/85025160773

U2 - 10.1039/c7cc03235h

DO - 10.1039/c7cc03235h

M3 - Article

C2 - 28692087

SN - 1359-7345

VL - 53

SP - 8328

EP - 8331

JO - Chemical Communications

JF - Chemical Communications

IS - 59

ER -

Ionic liquids with thioether motifs as synthetic cationic lipids for gene delivery

Abstract

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