Isomeric Co(ii) paraCEST agents as pH responsive MRI probes

Christopher J. Bond; Roy Cineus; Alexander Y. Nazarenko; Joseph A. Spernyak; Janet R. Morrow

doi:10.1039/c9dt04558a

Isomeric Co(ii) paraCEST agents as pH responsive MRI probes

Christopher J. Bond
, Roy Cineus
, Alexander Y. Nazarenko
, Joseph A. Spernyak
, Janet R. Morrow

Chemistry

University at Buffalo

SUNY Buffalo
Buffalo State College, State University of New York
Roswell Park Cancer Institute

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

A newly discovered isomer of Co(ii) (1,4,8,11-tetrakis(carbamoylmethyl)-1,4,8,11-tetraazacyclotetradecane = CCRM) produces four highly paramagnetically shifted chemical exchange saturation transfer (CEST) peaks. The 1,8-pendants of the complex are bound in a trans-arrangement to produce a Co(ii) complex of increased kinetic inertness. The isomers have a stabilized Co(ii) center (E_1/2 of 540 to 550 mV versus SHE). Both the 1,8 and the 1,4-isomer are excellent pH probes in solution and in tissue homogenate by virtue of their highly paramagnetically shifted amide protons. These isomers produce both a ratiometric pH readout as well as amide proton exchange rate constants that correlate to pH.

Original language	English
Pages (from-to)	279-284
Number of pages	6
Journal	Dalton Transactions
Volume	49
Issue number	2
DOIs	https://doi.org/10.1039/c9dt04558a
State	Published - 2020

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title = "Isomeric Co(ii) paraCEST agents as pH responsive MRI probes",

abstract = "A newly discovered isomer of Co(ii) (1,4,8,11-tetrakis(carbamoylmethyl)-1,4,8,11-tetraazacyclotetradecane = CCRM) produces four highly paramagnetically shifted chemical exchange saturation transfer (CEST) peaks. The 1,8-pendants of the complex are bound in a trans-arrangement to produce a Co(ii) complex of increased kinetic inertness. The isomers have a stabilized Co(ii) center (E1/2 of 540 to 550 mV versus SHE). Both the 1,8 and the 1,4-isomer are excellent pH probes in solution and in tissue homogenate by virtue of their highly paramagnetically shifted amide protons. These isomers produce both a ratiometric pH readout as well as amide proton exchange rate constants that correlate to pH.",

author = "Bond, \{Christopher J.\} and Roy Cineus and Nazarenko, \{Alexander Y.\} and Spernyak, \{Joseph A.\} and Morrow, \{Janet R.\}",

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doi = "10.1039/c9dt04558a",

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T1 - Isomeric Co(ii) paraCEST agents as pH responsive MRI probes

AU - Bond, Christopher J.

AU - Cineus, Roy

AU - Nazarenko, Alexander Y.

AU - Spernyak, Joseph A.

AU - Morrow, Janet R.

PY - 2020

Y1 - 2020

N2 - A newly discovered isomer of Co(ii) (1,4,8,11-tetrakis(carbamoylmethyl)-1,4,8,11-tetraazacyclotetradecane = CCRM) produces four highly paramagnetically shifted chemical exchange saturation transfer (CEST) peaks. The 1,8-pendants of the complex are bound in a trans-arrangement to produce a Co(ii) complex of increased kinetic inertness. The isomers have a stabilized Co(ii) center (E1/2 of 540 to 550 mV versus SHE). Both the 1,8 and the 1,4-isomer are excellent pH probes in solution and in tissue homogenate by virtue of their highly paramagnetically shifted amide protons. These isomers produce both a ratiometric pH readout as well as amide proton exchange rate constants that correlate to pH.

AB - A newly discovered isomer of Co(ii) (1,4,8,11-tetrakis(carbamoylmethyl)-1,4,8,11-tetraazacyclotetradecane = CCRM) produces four highly paramagnetically shifted chemical exchange saturation transfer (CEST) peaks. The 1,8-pendants of the complex are bound in a trans-arrangement to produce a Co(ii) complex of increased kinetic inertness. The isomers have a stabilized Co(ii) center (E1/2 of 540 to 550 mV versus SHE). Both the 1,8 and the 1,4-isomer are excellent pH probes in solution and in tissue homogenate by virtue of their highly paramagnetically shifted amide protons. These isomers produce both a ratiometric pH readout as well as amide proton exchange rate constants that correlate to pH.

UR - https://www.scopus.com/pages/publications/85077402832

U2 - 10.1039/c9dt04558a

DO - 10.1039/c9dt04558a

M3 - Article

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SN - 1477-9226

VL - 49

SP - 279

EP - 284

JO - Dalton Transactions

JF - Dalton Transactions

IS - 2

ER -

Isomeric Co(ii) paraCEST agents as pH responsive MRI probes

Abstract

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