Kainic acid responses and toxicity show pronounced Ca2+ dependence

N. Hori; J. M.H. Ffrench-Mullen; D. O. Carpenter

doi:10.1016/0006-8993(85)90989-8

Kainic acid responses and toxicity show pronounced Ca²⁺ dependence

N. Hori
, J. M.H. Ffrench-Mullen
, D. O. Carpenter

Environmental Health Sciences

University at Albany

Wadsworth Center for Laboratories and Research

Research output: Contribution to journal › Article › peer-review

47 Scopus citations

Abstract

Responses of pyramidal neurons to ionophoretic kainate, quisqualate and N-methyl aspartate were studied in a submerged rat piriform cortex slice as a function of Ca²⁺ and Mg²⁺ concentrations. The results suggest that (a) the channel activated by kainate is unusually influenced by Ca²⁺, (b) excitotoxicity is Ca²⁺-dependent and a function of Ca²⁺ concentration, and (c) the excitotoxic actions of various amino acid agonists are correlated with the Ca²⁺ dependence of their responses.

Original language	English
Pages (from-to)	380-384
Number of pages	5
Journal	Brain Research
Volume	358
Issue number	1-2
DOIs	https://doi.org/10.1016/0006-8993(85)90989-8
State	Published - Dec 9 1985

Keywords

calcium
excitotoxicity
kainate

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10.1016/0006-8993(85)90989-8

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title = "Kainic acid responses and toxicity show pronounced Ca2+ dependence",

abstract = "Responses of pyramidal neurons to ionophoretic kainate, quisqualate and N-methyl aspartate were studied in a submerged rat piriform cortex slice as a function of Ca2+ and Mg2+ concentrations. The results suggest that (a) the channel activated by kainate is unusually influenced by Ca2+, (b) excitotoxicity is Ca2+-dependent and a function of Ca2+ concentration, and (c) the excitotoxic actions of various amino acid agonists are correlated with the Ca2+ dependence of their responses.",

keywords = "calcium, excitotoxicity, kainate",

author = "N. Hori and Ffrench-Mullen, \{J. M.H.\} and Carpenter, \{D. O.\}",

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T1 - Kainic acid responses and toxicity show pronounced Ca2+ dependence

AU - Hori, N.

AU - Ffrench-Mullen, J. M.H.

AU - Carpenter, D. O.

PY - 1985/12/9

Y1 - 1985/12/9

N2 - Responses of pyramidal neurons to ionophoretic kainate, quisqualate and N-methyl aspartate were studied in a submerged rat piriform cortex slice as a function of Ca2+ and Mg2+ concentrations. The results suggest that (a) the channel activated by kainate is unusually influenced by Ca2+, (b) excitotoxicity is Ca2+-dependent and a function of Ca2+ concentration, and (c) the excitotoxic actions of various amino acid agonists are correlated with the Ca2+ dependence of their responses.

AB - Responses of pyramidal neurons to ionophoretic kainate, quisqualate and N-methyl aspartate were studied in a submerged rat piriform cortex slice as a function of Ca2+ and Mg2+ concentrations. The results suggest that (a) the channel activated by kainate is unusually influenced by Ca2+, (b) excitotoxicity is Ca2+-dependent and a function of Ca2+ concentration, and (c) the excitotoxic actions of various amino acid agonists are correlated with the Ca2+ dependence of their responses.

KW - calcium

KW - excitotoxicity

KW - kainate

UR - https://www.scopus.com/pages/publications/0022399251

U2 - 10.1016/0006-8993(85)90989-8

DO - 10.1016/0006-8993(85)90989-8

M3 - Article

C2 - 2416390

SN - 0006-8993

VL - 358

SP - 380

EP - 384

JO - Brain Research

JF - Brain Research

IS - 1-2

ER -

Kainic acid responses and toxicity show pronounced Ca²⁺ dependence

Abstract

Keywords

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