Lbx1 acts as a selector gene in the fate determination of somatosensory and viscerosensory relay neurons in the hindbrain

Martin A. Sieber; Robert Storm; Margaret Martinez-de-la-Torre; Thomas Müller; Hagen Wende; Katja Reuter; Elena Vasyutina; Carmen Birchmeier

doi:10.1523/JNEUROSCI.0717-07.2007

Lbx1 acts as a selector gene in the fate determination of somatosensory and viscerosensory relay neurons in the hindbrain

Martin A. Sieber
, Robert Storm
, Margaret Martinez-de-la-Torre
, Thomas Müller
, Hagen Wende
, Katja Reuter
, Elena Vasyutina
, Carmen Birchmeier

Medicine

Upstate Medical University

Max Delbrück Center for Molecular Medicine in the Helmholtz Association
Bayer AG
University of Murcia

Research output: Contribution to journal › Article › peer-review

102 Scopus citations

Abstract

Distinct types of relay neurons in the hindbrain process somatosensory or viscerosensory information. How neurons choose between these two fates is unclear. We show here that the homeobox gene Lbx1 is essential for imposing a somatosensory fate on relay neurons in the hindbrain. In Lbx1 mutant mice, viscerosensory relay neurons are specified at the expense of somatosensory relay neurons. Thus Lbx1 expression distinguishes between the somatosensory or viscerosensory fate of relay neurons.

Original language	English
Pages (from-to)	4902-4909
Number of pages	8
Journal	Journal of Neuroscience
Volume	27
Issue number	18
DOIs	https://doi.org/10.1523/JNEUROSCI.0717-07.2007
State	Published - May 2 2007

Keywords

Development
Genetic lineage tracing
Homeobox gene
Neuronal specification
Nucleus of the solitary tract
Spinal trigeminal nucleus

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10.1523/JNEUROSCI.0717-07.2007

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abstract = "Distinct types of relay neurons in the hindbrain process somatosensory or viscerosensory information. How neurons choose between these two fates is unclear. We show here that the homeobox gene Lbx1 is essential for imposing a somatosensory fate on relay neurons in the hindbrain. In Lbx1 mutant mice, viscerosensory relay neurons are specified at the expense of somatosensory relay neurons. Thus Lbx1 expression distinguishes between the somatosensory or viscerosensory fate of relay neurons.",

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AU - Sieber, Martin A.

AU - Storm, Robert

AU - Martinez-de-la-Torre, Margaret

AU - Müller, Thomas

AU - Wende, Hagen

AU - Reuter, Katja

AU - Vasyutina, Elena

AU - Birchmeier, Carmen

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AB - Distinct types of relay neurons in the hindbrain process somatosensory or viscerosensory information. How neurons choose between these two fates is unclear. We show here that the homeobox gene Lbx1 is essential for imposing a somatosensory fate on relay neurons in the hindbrain. In Lbx1 mutant mice, viscerosensory relay neurons are specified at the expense of somatosensory relay neurons. Thus Lbx1 expression distinguishes between the somatosensory or viscerosensory fate of relay neurons.

KW - Development

KW - Genetic lineage tracing

KW - Homeobox gene

KW - Neuronal specification

KW - Nucleus of the solitary tract

KW - Spinal trigeminal nucleus

UR - https://www.scopus.com/pages/publications/34247890152

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SN - 0270-6474

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SP - 4902

EP - 4909

JO - Journal of Neuroscience

JF - Journal of Neuroscience

IS - 18

ER -

Lbx1 acts as a selector gene in the fate determination of somatosensory and viscerosensory relay neurons in the hindbrain

Abstract

Keywords

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