Light-Driven Translocation of Signaling Proteins in Vertebrate Photoreceptors

P. D. Calvert; V. Y. Arshavsky

doi:10.1016/B978-0-443-13820-1.00066-9

Light-Driven Translocation of Signaling Proteins in Vertebrate Photoreceptors

P. D. Calvert
, V. Y. Arshavsky

Upstate Medical University

Duke University

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

Abstract

Sustained illumination causes massive translocation of three signal transduction proteins, transducin, arrestin and recoverin, into and out of the outer segment compartment of rod and cone photoreceptors. This phenomenon is thought to contribute to photoreceptor adaptation to diurnal changes in ambient light intensity and likely to photoreceptor neuroprotection from the adverse effects of bright light illumination.

Original language	English
Title of host publication	Encyclopedia of the Eye
Publisher	Elsevier
Pages	V3:22-V3:27
ISBN (Electronic)	9780443138201
ISBN (Print)	9780443138393
DOIs	https://doi.org/10.1016/B978-0-443-13820-1.00066-9
State	Published - Jan 1 2025

Keywords

Arrestin
Diffusion
Light adaptation
Photoreceptor
Phototransduction
Protein translocation
Recoverin
Transducin

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10.1016/B978-0-443-13820-1.00066-9

Cite this

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abstract = "Sustained illumination causes massive translocation of three signal transduction proteins, transducin, arrestin and recoverin, into and out of the outer segment compartment of rod and cone photoreceptors. This phenomenon is thought to contribute to photoreceptor adaptation to diurnal changes in ambient light intensity and likely to photoreceptor neuroprotection from the adverse effects of bright light illumination.",

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N2 - Sustained illumination causes massive translocation of three signal transduction proteins, transducin, arrestin and recoverin, into and out of the outer segment compartment of rod and cone photoreceptors. This phenomenon is thought to contribute to photoreceptor adaptation to diurnal changes in ambient light intensity and likely to photoreceptor neuroprotection from the adverse effects of bright light illumination.

AB - Sustained illumination causes massive translocation of three signal transduction proteins, transducin, arrestin and recoverin, into and out of the outer segment compartment of rod and cone photoreceptors. This phenomenon is thought to contribute to photoreceptor adaptation to diurnal changes in ambient light intensity and likely to photoreceptor neuroprotection from the adverse effects of bright light illumination.

KW - Arrestin

KW - Diffusion

KW - Light adaptation

KW - Photoreceptor

KW - Phototransduction

KW - Protein translocation

KW - Recoverin

KW - Transducin

UR - https://www.scopus.com/pages/publications/105028826108

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DO - 10.1016/B978-0-443-13820-1.00066-9

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SP - V3:22-V3:27

BT - Encyclopedia of the Eye

PB - Elsevier

ER -

Light-Driven Translocation of Signaling Proteins in Vertebrate Photoreceptors

Abstract

Keywords

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