Low-coherence optical tomography in turbid tissue: Theoretical analysis

Yingtian Pan; Reginald Birngruber; Jürgen Rosperich; Ralf Engelhardt

doi:10.1364/AO.34.006564

Low-coherence optical tomography in turbid tissue: Theoretical analysis

Yingtian Pan
, Reginald Birngruber
, Jürgen Rosperich
, Ralf Engelhardt

Biomedical Engineering

Stony Brook University

Ger

Research output: Contribution to journal › Article › peer-review

178 Scopus citations

Abstract

On the basis of white-light interferometry and statistical optics, a theoretical model for low-coherence optical tomography is presented that establishes the relation of interference modulation with path-length-resolved reflectance and that can provide analytical expressions and numerical solutions by means of a Fourier transform. The Monte Carlo technique is used to simulate the path-length-resolved reflectance from different multilayer tissue phantoms. Theoretical analyses and preliminary experimental results suggest that, unlike time-resolved spectroscopy, low-coherence optical tomography detects the local relative variations of path-length-resolved reflectance from the turbid tissues.

Original language	English
Pages (from-to)	6564-6574
Number of pages	11
Journal	Applied Optics
Volume	34
Issue number	28
DOIs	https://doi.org/10.1364/AO.34.006564
State	Published - Oct 1995

Keywords

Coherence-gated imaging
Fourier transform
Low-coherence interferometry
Path-lengthresolved Monte Carlo simulation
Tissue-optical properties

Access to Document

10.1364/AO.34.006564

Cite this

@article{add48edd8ab74d31877150ccc81e99bb,

title = "Low-coherence optical tomography in turbid tissue: Theoretical analysis",

abstract = "On the basis of white-light interferometry and statistical optics, a theoretical model for low-coherence optical tomography is presented that establishes the relation of interference modulation with path-length-resolved reflectance and that can provide analytical expressions and numerical solutions by means of a Fourier transform. The Monte Carlo technique is used to simulate the path-length-resolved reflectance from different multilayer tissue phantoms. Theoretical analyses and preliminary experimental results suggest that, unlike time-resolved spectroscopy, low-coherence optical tomography detects the local relative variations of path-length-resolved reflectance from the turbid tissues.",

keywords = "Coherence-gated imaging, Fourier transform, Low-coherence interferometry, Path-lengthresolved Monte Carlo simulation, Tissue-optical properties",

author = "Yingtian Pan and Reginald Birngruber and J{\"u}rgen Rosperich and Ralf Engelhardt",

year = "1995",

month = oct,

doi = "10.1364/AO.34.006564",

language = "English",

volume = "34",

pages = "6564--6574",

journal = "Applied Optics",

issn = "1559-128X",

publisher = "Optica Publishing Group",

number = "28",

}

TY - JOUR

T1 - Low-coherence optical tomography in turbid tissue

T2 - Theoretical analysis

AU - Pan, Yingtian

AU - Birngruber, Reginald

AU - Rosperich, Jürgen

AU - Engelhardt, Ralf

PY - 1995/10

Y1 - 1995/10

N2 - On the basis of white-light interferometry and statistical optics, a theoretical model for low-coherence optical tomography is presented that establishes the relation of interference modulation with path-length-resolved reflectance and that can provide analytical expressions and numerical solutions by means of a Fourier transform. The Monte Carlo technique is used to simulate the path-length-resolved reflectance from different multilayer tissue phantoms. Theoretical analyses and preliminary experimental results suggest that, unlike time-resolved spectroscopy, low-coherence optical tomography detects the local relative variations of path-length-resolved reflectance from the turbid tissues.

AB - On the basis of white-light interferometry and statistical optics, a theoretical model for low-coherence optical tomography is presented that establishes the relation of interference modulation with path-length-resolved reflectance and that can provide analytical expressions and numerical solutions by means of a Fourier transform. The Monte Carlo technique is used to simulate the path-length-resolved reflectance from different multilayer tissue phantoms. Theoretical analyses and preliminary experimental results suggest that, unlike time-resolved spectroscopy, low-coherence optical tomography detects the local relative variations of path-length-resolved reflectance from the turbid tissues.

KW - Coherence-gated imaging

KW - Fourier transform

KW - Low-coherence interferometry

KW - Path-lengthresolved Monte Carlo simulation

KW - Tissue-optical properties

UR - https://www.scopus.com/pages/publications/65949113578

U2 - 10.1364/AO.34.006564

DO - 10.1364/AO.34.006564

M3 - Article

SN - 1559-128X

VL - 34

SP - 6564

EP - 6574

JO - Applied Optics

JF - Applied Optics

IS - 28

ER -

Low-coherence optical tomography in turbid tissue: Theoretical analysis

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this